1992 Fiscal Year Final Research Report Summary
Basic Genetic Studies Related to OPLL
| Project/Area Number |
02454343
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Orthopaedic surgery
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
FURUYA Kohtaro Faculty of Medicine, Tokyo medical and Dental Univ. Professor, 医学部, 教授 (30013915)
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| Co-Investigator(Kenkyū-buntansha) |
FURUSHO Toshiyuki Faculty of Health Sciences, Kyorin Univ. Professor, 保健学部, 教授 (80013910)
NAKAJIMA Hachiro Faculty of Medicine, Tokyo medical and Dental Univ. Associate Professor, 医学部, 助教授 (30013882)
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| Project Period (FY) |
1990 – 1992
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| Keywords | OPLL / Linkage Analysis / Blood Groops / Genetic Markers / Gene Locus / Chromosome / DNA-Diagnosis |
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| Research Abstract |
In an attempt to identity the gene locus for OPLL, and to develop the basis for diagnosis by DNA analysis, the linkage between the genes in OPLL cases and 16 genetic markers, from 7 blood groups 6 serum protein groups and 3 erythrocyte enzyme systems were studied. Eleven families were studied, with a total of 47 individuals who were examined by X-ray and for genetic markers. Nine of the families were studied over 2 generations, and one family over 3 generations. OPLL was confirmed over 2 generations in 2 families. There were no confirmed cases seen over 3 generations. Because of late onset of disease in the case of OPLL, the third generation was too young to express the disease. Linkage analysis of OPLL was therefore not possible. In diseases with late onset, a one-time examination would not appear to be adequate for confirmation of diseases' presence or absence. Repeated periodic examinations with 5 to 10 year intervals appear to be indicated. Results of chromosomal analysis showed no chromosomal aberrations significantly and directory related to OPLL onset or development.
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