1992 Fiscal Year Final Research Report Summary
A Study of Interaction between Egg and Endometrium in Implantation.
| Project/Area Number |
02454377
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Obstetrics and gynecology
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| Research Institution | University of Tokyo |
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Principal Investigator |
TAKETANI Yuji University of Tokyo, Faculty of Medicine, Department of Obstetrics and Gynecology.Professor., 医学部(病), 教授 (10114539)
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| Co-Investigator(Kenkyū-buntansha) |
SHAN-GUANG Liang University of Tokyo, Faculty of Medicine, Department of Obstetrics and Gynecolog, 医学部(病), 助手 (20220808)
TUTUMI Osamu University of Tokyo, Faculty of Medicine, Department of Obstetrics and Gynecolog, 医学部(病), 講師 (60134574)
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| Project Period (FY) |
1990 – 1992
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| Keywords | implantation / epidermal growth factor / endometrium / prostaglandin / tissue-plasminogen activator / EGF receptor / folliculogenesis / embryogenesis |
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| Research Abstract |
The present study was undertaken to investigate the mechanism of implantation taking the embryo-maternal interaction into account. First of all, epidermal growth factor (EGF) -like immunoreactivity was demonstrated in human endometrium along with the receptor for EGF.In primary cell culture of human endometrial cells, EGF stimulated the release of both prostaglandin and tissue-plasminogen activator which are supposed to be involved in implantation. EGF was further shown to enhance glycogenolysis so as to supply embryos with glucose requires for nidation. Altogether, EGF is implicated to have a role in implantation. Another finding with EGF is that estradiol increased the amount of EGF receptor in combination with progesterone in human endometrial cells. As for folliculogenesis, EGF stimulated the proliferation of cultured rat granulosa cells in concert with FSH.In view of the presence of EGF-like substance in the ovaries, EGF is assumed to regulate folliculogenesis. In addition, EGF stimulated the development of mouse 2-cell embryo in vitro. Thus, it appears that EGF has diverse biological actions in reproduction, such as folliculogenesis, embryonal development and implantation, etc.
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