1992 Fiscal Year Final Research Report Summary
Mechnism of anti-atherogenic action of Eicosapentaenoic acid(EPA).
| Project/Area Number |
02454505
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内分泌・代謝学
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| Research Institution | Chiba University Medical School |
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Principal Investigator |
TAMURA Yasushi Chiba Univ. Med. School Asso. Prof., 医学部, 助教授 (90009671)
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| Co-Investigator(Kenkyū-buntansha) |
TERANO Takashi Chiba Univ.Med.School Assistant, 医学部, 助手 (70237006)
HIRAI Aizan Chiba Univ.Med.School Assistant, 医学部, 助手 (10189813)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Eicosapentaenoic acid / Cholesterol / Macrophage / Oxidative-LDL / Prostacycline / Lipid peroxides |
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| Research Abstract |
1)Inhibition of foam cell formation by EPA Accumulation of cholesterol was sigunificantly decreased in EPA-rich peritoneal macrophages obtanined from rats fed with purified EPA-E. In addition receptor numbers of acetylated LDL and PDGF production were decreased in EPA-rich rat pineal macrophages. 2)Suppresion of oxidative modification of EPA-rich rabbit LDL. EPA-rich LDL obtained from rabbits fed with purified EPA-E showed a lesser susceptibility to Ca^<++>-catalysed oxidative modification. 3)Study of the effect of EPA on cells enriched with EPA. EPA suppressed proliferation of cultured rat vascular smooth muscle cell enriched with EPA. DHA had a similar effect, but lesser than EPA. 4)Effect of PGI_2 production in EPA-rich rat vascular smooth muscle cells. Enhanced PGI_2 synthesis was noted in EPA-enriched rat vascular smooth muscle cells. This could be most likely explained by stimulation of cyclooxygenase activity by lipid peroxides derived from EPA.
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