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1991 Fiscal Year Final Research Report Summary

Brainstem mechanisms of otolith-visual interaction in the control of eye movement produced by sinusoidal vertical linear acceleration

Research Project

Project/Area Number 02670044
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionHokkaido University

Principal Investigator

FUKUSHIMA Kikuro  Hokkaido University School of Medicine Associate professor, 医学部, 助教授 (70091486)

Project Period (FY) 1990 – 1991
KeywordsOtolith / Vertical linear acceleration / Eye movement / Otolith-ocular reflex / Interstitial nucleus of Cajal / Vestibular nuclei / Otolith-visual interaction / Alert cat
Research Abstract

Eye movement responses were examined in alert during sinusoidal vertical linear acceleration at 0.20-0.85Hz with an amplitude of 10.5cm (corresponding to 0.02-0.31g). Sinusoidal linear acceleration in the light produced robust eye movement responses with near compensatory phase at all stimulus frequencies tested. In the dark, however, only small responses with advanced phase (by 70゚) were obtained. Optokinetic stimulation alone produced more lag of response phase with smaller gain as stimulus frequency increased. Linear acceleration in cats that had received bilateral labyrinthectomies resulted in more phase lag at higher stimulus frequencies and decreased gain at all frequencies tested. These results indicate that the interaction of otolith and visual inputs produces robust eye movement responses with near compensatory phase during sinusoidal linear acceleration in the light.
To examine brainstem mechanisms for this interaction, neuronal activity was recorded in the interstitial nucleu … More s of Cajal (INC) and vestibular nuclei (VN). Activity of all eye movement-related burst-tonic (BT) and tonic (T) neurons in the INC was modulated in correlation to eye movement responses in the light. However, in the dark, most of them (84%) did not respond. The remaining cells responded to linear acceleration ; their mean phase values advanced by 801 and gain dropped by 55% compared to the responses in the light. These results suggest that the otolith-visual interaction occurs before the level of these neurons. Many INC cells other than BT and T cells responded to linear acceleration in the dark and optokinetic stimulation, indicating that these cells received otolith and visual inputs. Responses of some of these cells during linear acceleration in the light could be explained by addition of otolith and visual inputs. Many VN cells that responded to pitch rotation, including cells with vertical eye position sensitivity, did not respond to linear acceleration in the dark. A minority of VN cells responded to linear acceleration in the dark. These results suggest that the otolith-visual interaction may occur both in the INC and VN at neurons that do not have eye position sensitivity. Less

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] Fukushima K: "Otolith-visual interaction in the control of eye movement produced by sinusoidal vertical linear acceleration in alert cats." Exp Brain Res. 85. 36-44 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Activity of eye movement-related neurons in the interstitial nucleus of Cajal region during sinusoidal vertical linear acceleration and optokinetic stimuli." Exp Brain Res. 85. 45-54 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "The intersitial nucleus of Cajal in the midbrain reticular formation and vertical eye movement." Neurosci Res. 10. 159-187 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Eye movement and neuronal response in the region of the intersitial nucleus of Cajal during sinusoidal vertical linear acceleration in alert cats." Acta Otolaryngol(Stockh). Suppl481. 37-41 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Latenices of response of eye movement related-ueurons in the region of the interstitial nucleus of Cajal to electrical stimulation of the vestibular nerve in alert cats." Exp Brain Res. 71. 254-258 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "The origin of regularity of discharge rates of eye movement-related neurons in the region of the interstitial nucleus of Cajal." Neurosci Res. 12. 379-387 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci Res. 12. 536-544 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrintheetomized cats." Neurosci Res.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "The neuronal substrate of integration in the oculomotor system." Prog Neurobiol.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Head-neck sensory motor system" Oxford University Press,New York, 748 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Vestibular and brain stem control of eye,head and body movements" Japan Scientific Societies Press,Tokyo,

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fukushima K: "Otolith-visual interaction in the control of eye movement produced by sinusoidal vertical linear acceleration in alert cats." Exp Brain Res. 85. 36-44 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "Activity of eye movement-related neurons in and near the interstitial nucleus of Cajal during sinusoidal vertical linear acceleration and optokinetic stimuli." Exp Brain Res. 85. 45-54 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "The interstitial nucleus of Cajal in the midbrain reticular formation and vertical eye movement." Neurosci Res. 10. 159-187 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "Eye movement and neuronal response in the region of the interstitial nucleus of Cajal during sinusoidal vertical linear acceleration in alert cats." Acta Otolaryngol (Stockh). Suppl 481. 37-41 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "Latencies of response of eye movement related-neurons in the region of the interstitial nucleus of Cajal to electrical stimulation of the vestibular nerve in alert cats." Exp Brain Res. 71. 254-258 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "The origin of regularity of discharge rates of eye movement-related neurons in the region of the interstitial nucleus of Cajal." Neurosci. Res. 12. 379-387 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "Possible downward burster-driving neurons related to the anterior semicircular canal in the region of the interstitial nucleus of Cajal in alert cats." Neurosci. Res. 12. 536-544 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "Ocular torsion produced by unilateral chemical inactivation of the interstitial nucleus of Cajal in chronically labyrinthectomized cats." Neurosci Res.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: "The neuronal substrate of integration in the oculomotor system." Prog Neurobiol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: Oxford University Press. Head-neck sensory motor system, 1992 (748)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fukushima K: Japan Scientific Societies Press. Vestibular and brain stem control of eye, head and body movements,

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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