1991 Fiscal Year Final Research Report Summary
Chronic Toxicity of Gallium Arsenide and Indium Arsenide Intratracheally Instilled into Hamsters
| Project/Area Number |
02670222
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kyushu University |
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Principal Investigator |
HISANAGA Akira Kyushu University, Medicine, Assistant Professor, 医学部, 講師 (20128078)
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| Co-Investigator(Kenkyū-buntansha) |
HIRATA Miyuki Kyushu University, Medicine, Research Associate, 医学部, 助手 (30156674)
TANAKA Akiyo Kyushu University, Medicine, Research Associate, 医学部, 助手 (10136484)
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| Project Period (FY) |
1990 – 1991
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| Keywords | Intratracheal instillation / Semiconducing materials / Arsenic / Chronic toxicity / Indium / Indium arsenide / Tumorigenicity |
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| Research Abstract |
Comparative chronic toxicity, including tumorigenicity, of some semiconducting materials, or gallium arsenide (GaAs), lndium arsenide (1nAs) and indium phosphide (1np) were studied using in Syrian golden hamsters given intermittent intratracheal instillations. These 3 particulates characterized with a geometric mean diameter ranging from 3.2 um to 3.9 um. Hamsters were given each compounds containing a total dose of 3.75 mgAs (GaAs), 7.5 mgAs (lnAs) or 7.5 mgp (InP) by means of intratracheal instillations once a week for 15 weeks. As a control, hamsters were treated with only the vehicle, phosphate buffer solution. We had observed all hamsters for about 2 years.
1. GaAs particles produced relatively severe lung damage including alveolar cell hyperplasia and congestion with hemorrhage, and the survival was shortened significantly compared with a control group.
2. The InAs group exhibited obviously lower increasing ratio of body weight rather than the control group, but the survival rates were not differed among the InAs, InP and control groups through the experimintal period. These particles also produced severe lung damage including alveolar morbid change like proteinosis, alveolar cell hyperplasia and pulmonary emphysema.
3. In these 3 groups, no more tumors were observed in the lungs and the other organs compared with the control.
4. These particulates of semiconducting materials retained in the lungs at the site of instillations for more than 7 months, which was likely to cause chronic lung damage.
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