1992 Fiscal Year Final Research Report Summary
Superoxide dismutase 1 in patients with dementia of the Alzheimer type.
| Project/Area Number |
02670358
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurology
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| Research Institution | Tottori University |
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Principal Investigator |
URAKAMI Katsuya Tottori University, Department of Neurology, Assistant Lecturer, 医学部附属病院, 助手 (30213507)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAHASHI Kazuro Tottori University, Department of Neurology, Professor, 医学部, 教授 (10031965)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Dementia of the Alzheimer type / Superoxide dismutase / Skin fibroblast |
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| Research Abstract |
We examined superoxide dismutase (SOD) in patients with dementia of the Alzheimer type (DAT). The DAT patients were divided into two subgroups as follows : Alzheimer's disease (AD) that develops before 65 years of age and senile dementia of the Alzheimer type (SDAT) that develops after 65 years of age. We examined SOD levels in erythrocyte, serum, cerebrospinal fluid (CSF) and fibroblast. SOD levels in skin fibroblast of DAT showed abnormality. The change of SOD mRNA was closely correlate with that of protein levels of SOD. SOD in erythrocyte, serum and CSF in Parkinson's disease were significantly lower than those in controls.
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