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1992 Fiscal Year Final Research Report Summary

Ischemia induced ventricular arrhythemias in the presence of hypokalemia

Research Project

Project/Area Number 02670400
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionNagasaki University

Principal Investigator

YANO Katsusuke  Nagasaki University 3rd Dept of Int Med Professor of Medicine, 医学部, 教授 (50039864)

Co-Investigator(Kenkyū-buntansha) MITSUOKA Takao  Nagasaki University 3rd Dept of Int Med Assistant, 医学部, 助手
Project Period (FY) 1990 – 1992
Keywordschronic hypopotassemia / extracellular potassium / ventricular arrhythmias / coronary occlusion / coronary reperfusion / effective refractory period / intraventricular conduction time
Research Abstract

During acute ischemia, myocardial cells release potassium ion that accumulate in the extracellular space because of reduced blood flow. The resulting altered potasslum gradients induce injury currents and are accompanied by typical electrophysiologic changes, which predispose the heart to ventricular arrhythmias. The present study was designed to examine changes in extracellular potassium during coronary occlusion and subsequent reperfusion, susceptibility of the heart to ventricular arrhythmias and electrophysiologic properties of the heart during myocardial ischemia in the dog with chronic hypopotassemia. To produce chronic hypopotassemia 20 dogs were fed special low-potassium diet and intramuscular administration (once a day) of furosemide (10 mg) and to produce normopotassmia 20 dog were fed ordinary diet for 4 weeks. Programmed ventricular stimulation was performed for induction of ventricular arrhythmias and for determination of effective refractory period and intraventricular conduction time. Extracellular potassium activity was recorded at normal and ischemic area of the heart during occlusion of the anterior descending coronary artery (LAD) and subsequent reperfusion. Extracellular potassium in the ischemic area of the heart was progressively increased during coronary occlusion and rapidly reduced after coronary reperfusion in the hypopotassemia and normopotassemia groups. The magnitude of increase in extracellular potassium was not significantly different between the two groups. Incidence of ventricular arrhythmias, dispersion of effective refractory period and intraventricular conduction delay in the ischemic area of the heart were greater in the dog with hypopotassemia than in the dog with normopotassemla. In conclusion, changes in extracellular potassium during coronary artery occlusion and subsequent reperfusion have important roles in the genesis of the ventricular arrhythmias in the presence of chronic hypopotassemia.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] Yano,K Matsumoto Y,Hirata M,Hirata T,Hano O,Mistuoka T and Hashiba K: "Influence of sympathetic nerve activity onventricular arrhythmogenicity in the dog with chronic hypokalemia" Angiology. 42. 878-888 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yano K,Mitsuoka T,Hirata T,Hano,O hirata M,Matsumoto Y: "Effect of Bilateral stellectomy on electrical instabilityof the atrium in the dog with hypokalemia." PACE. 15. 314-323 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Katsusuke Yano: "Effect of left ventricular systolic pressure increase on ventricular arrhythmogenicity in old canine myocardial infarction" Cardiovascular Research. 26. 988-993 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yano K. Matsumoto Y. Hirata M. Hirata T. Hano O. Mitsuoka T and Hashiba K: "Influence of sympathetic nerve activity onventricular arrhythmogenicity in the dog with chronic hypokalemia" Angiology. 42. 878-888 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yano K. Mitsuoka T. Hirata T. Hano O, Hirata M. Matsumoto Y: "Effect of Bilateral stellectomy on electrical instability of the atrium in the dog with hypokalemia" PACE. 15. 314-323 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Katsusuke Yano: "Effect of left ventricular systolic pressure increase on ventricular arrhythmogenicity in old canine myocardial infarction" Cardiovascular Research. 26. 988-993 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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