1992 Fiscal Year Final Research Report Summary
A study of signal transduction of PGE_2 and TXA_2 receptor in nephrotic rat kidney
| Project/Area Number |
02670453
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Fukushima Medical College |
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Principal Investigator |
SUZUKI Junzo Fukushima Medical College, Pediatrics, Research Associate, 医学部小児科学講座, 講師 (20171217)
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| Co-Investigator(Kenkyū-buntansha) |
SUZUKI Hitoshi Fukushima Medical College, Pediatrics, Professor, 医学部小児科学講座, 教授 (80045682)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Signal transduction / TXA_2 receptor / PGE_2 receptor / Phosphatidylinositol / Nephrotic syndrome / Aminonucleoside nephrotic rat / Corticosteroid / Sairei-to |
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| Research Abstract |
Prostaglandin(PG)E_2- and thromboxane(TX)A_2- induced signal transduction were investigated in preparations derived from normal and puromycin aminonucleoside (AN) nephrotic rat (NR) kidneys.
The obtained results were as follows :
1) TXA_2 & PGE_2 production in the glomeruli of the ANNR were significantly greater than that in the glomeruli of the control rat.
2) PGE_2 receptors of the normal rat kidney were distributed in the medulla more than in the cortex, but TXA_2 receptors were in the cortex more than in the medulla.
3) The affinities of PGE_2 and TXA_2 receptors in ANNR kidneys were lower than those in normal rat kidneys.
4) Phosphatidylinositol(PI) breakdown was elicited by PGE_2 dose-dependently, and PGE_2-induced PI breakdown was significantly suppressed in ANNR kidneys.
5) The affected responsiveness of the PI breakdown system to PGE_2 in ANNR kidneys was presumed to be normalized by corticosteroid and/or Sairei-to.
These results indicate that the signal transduction of PGE_2 and/or TXA_2 receptors may be damaged in ANNR kidneys. Therefore, PGE_2 and/or TXA_2 receptors were considered to play an important role in a pathophysiology of the signal transduction in the nephrotic syndrome.
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Research Products
(18 results)
