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1991 Fiscal Year Final Research Report Summary

Assessment of response to cancer therapy by tumor blood flow and metabolism : A PET study

Research Project

Project/Area Number 02670500
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Radiation science
Research InstitutionKyushu University

Principal Investigator

ICHIYA Yuichi  Kyushu University Faculty of Medicine, Lecturer, 医学部, 講師 (00117425)

Co-Investigator(Kenkyū-buntansha) SASAKI Masayuki  Kyushu University Faculty of Medicine, Resident, 医学部, 医員
FUKUMURA Toshimitsu  Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (90199266)
OTSUKA Makoto  Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (60203840)
KUWABARA Yasuo  Kyushu University Faculty of Medicine, Assistant, 医学部, 助手 (30150436)
Project Period (FY) 1990 – 1991
KeywordsF-18 fluorodeoxyglucose / Tumor metabolism / Glucose Metabolism / Positron CT
Research Abstract

In order to evaluate the role of measurement of metabolic alteration of the tumors in the assessment of therapeutic effects, positron emission tomography (PET) using F-18 2-fluoro-2-deoxy-D-glucose (FDG) (FDG-PET) were performed before and/or after therapy in 90 patients with malignant tumors including bronchogenic carcinomas, hepatomas, thyroid cancers and mediastinal tumors. The change in FDG uptake by therapy was compared, with the change of the tumor size. In this series, all malignant lesions had high FDG uptake before therapy. The lesions which had relatively low FDG uptake before therapy did not respond to the therapy. Decreased FDG uptake after therapy was more prominent in the responded group than in the non-responded group. Some of the patients with a decreased FDG uptake after therapy, though tumor sizes did not decreased, had no recurrence. This indicates the possibility of FDG assessing the therapeutic effects in the no change group. A decrease of FDG uptake after therapy did not necessarily indicate a good prognosis, and change of FDG uptake had no value in predicting the prognosis. These results suggest a complementary role of FDG-PET in the assessment of therapeutic effect. We also measured tumor blood flow preliminarily in five patients with malignant tumors using 0-15 water and PET. However, no correlation was noted between tumor blood flow and therapeutic response.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Y.Ichiya: "Assessment of F-18 EDG-PET in the management of cancer therapy." Journal of Nuclear Medicine. 31. 889 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 一矢 有一: "肺癌におけるFー18FDGーPET:特に治療効果との関係について" 日本医学放射線学会誌. 51. S91 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 一矢 有一: "腫瘍の循環代謝からみた治療効果判定ならびに予後予測に関する研究:ポジトロンCTによる検討." Innervision. 6. 43-44 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y.Ichiya: "Assessment of response to cancer therapy using Fluorine-18-fluorodeoxyglucose and positron emission tomography" Journal of Nuclear Medicine. 32. 1655-1660 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 一矢 有一: "甲状腺癌全摘後症例における ^<18>FDGーPETによる転移巣の描出" 核医学. 28. 955 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 一矢 有一: "ポジトロンCTによる癌の診断" 病態生理. 10. 957-962 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Y. Ichiya: "Assessment of F-18 FDG-PET in the management of cancer therapy." Journal of Nuclear Medicine. 31(5). 889 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichiya: "F-18 FDG-PET in patients with bronchogenic carcinoma." Nippon Acta Radiologica. 51, suppl. S90 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichiya: "Assessment of Response to Cancer Therapy by tumor blood flow and metabolism : A PET study" Innervision. 6(7). 43-44 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichiya: "Detection of metastatic foci of thyroid cancer using F-18 FDG PET in thyroidectiomized patients." Japanese Journal of Nuclear Medicine. 28(8). 955 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichiya: "Assessment of response to cancer therapy using Fluorine 18-Fluorodeoxyglucose and positron emission tomography." Journal of Nuclear Medicine. 32(9). 1655-1660 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Y. Ichiya: "Positron emission tomography in cancer diagnosis." Medicina Philosophica. 10(12). 957-962 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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