1991 Fiscal Year Final Research Report Summary
A Study on a New Method for Autologous Blood Transfusion Using Recombinant Human Erythropoietin
| Project/Area Number |
02670555
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | Saitama Medical School |
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Principal Investigator |
MAEDA Hiroo Saitama Medical School, Faculty of Medicine, Associated Professor, 医学部, 助教授 (30134597)
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| Co-Investigator(Kenkyū-buntansha) |
HITOMI Yuko Saitama Medical School, Faculty of Medicine, Assistant Professor, 医学部, 助手 (80181105)
TOHYAMA Hiroshi Saitama Medical School, Faculty of Medicine, Professor, 医学部, 教授 (00008278)
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| Project Period (FY) |
1990 – 1991
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| Keywords | Autologous blood transfusion / Recombinant human erythropoietin / Post-transfusion hepatitis |
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| Research Abstract |
To avoid the side effects by homologous blood transfusion, we conducted predeposit autologous blood transfusion in patients undergoing orthopedic surgery with or without use of recombinant human erythropoietin (rHu-EPO). The patients not given rHu-EPO donated 400 ml of blood weekly for 3 weeks, a total of 1, 200 ml, before operation, unless the hemoglobin (Hb) value was less than 11.0 g/dl (the control group). In the same protocol, the patients given rHu-EPO (Chugai Pharmaceutical, Tokyo) twice or thrice a week for 4 weeks before operation also donated 1, 200 ml of autologous blood (the EPO 2/W and EPO 3/W groups). Ten of 12 patients in the control group succeeded in donating 1, 200 ml of blood, but the Hb value of 13.8 g/dl at predonation dropped to 10.9 g/dl after 1, 200 ml donation. All patients in the EPO group donated 1, 200 ml of blood and the Hb values of 13.0 g/dl and 12.7 g/dl in the EPO 2/W and 3/W groups at predonation only slightly decreased to 12.0 g/dl and 12.0 g/dl after donation, respectively. The decreased Hb value of 2.9 g/dl in the control group was significantly greater than those of the EPO group (1.0 g/dl in the EPO 2/W and 0.7 g/dl in the EPO 3/W group). The postoperative nadir of the Hb value in the control group was 8.0 g/dl and three patients in the control required homologous transfusion. The nadir of the Hb values in the EPO 2/W and 3/W group was 9.2 and 10.0 g/dl, respectively and none required homologous blood transfusion. rHu-EPO was efficacious in preventing the donor/patients from anemia induced by donations and useful in avoiding homologous blood transfusion.
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