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1992 Fiscal Year Final Research Report Summary

Metastatic mechanism of bone and soft tissue tumors from the view point of matrix-metalloproteinases

Research Project

Project/Area Number 02670671
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Orthopaedic surgery
Research InstitutionKurume University

Principal Investigator

KOMIYA Setsurou  Dept. of Orthopedics Kurume Med.school Lecturer, 医学部・整形外科, 講師 (30178371)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Sanshiro  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手
HIRAOKA Kohji  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手
MINAMITANI Kazuhito  Dept. of Orthopedics Kurume Med.school Fellow, 医学部・整形外科, 助手 (80248434)
Project Period (FY) 1990 – 1992
KeywordsMetastasis / Bone tumor / Soft part tumor / Basement membrane / Matrix-metalloproteinase / Osteoclast / 骨吸収活性
Research Abstract

Various cell lines derived from bone and soft tissue tumors have been established.
They include 4 osteosarcomas, 2 chondrosarcomas, 4 metastatic bone cancers, 4 malignant fibrous histiocytoma, and 3 giant cell tumor of bones. Cell lines with high potentiality for pulmonary metastasis showed multiple gelatinolytic activities.
These activities were changeable depending on the matrices surrounding the cells. Some cells revealed an MMP-2 activity of Mr of 92KDa. Interleukin 1 (IL-1) stimulated well the cells to generate MMPs which might degradate the basement membrane.
Osteoclast-like giant cells were certified histochemically to produce IL-1. Osteoclast may play a role to stimulate tumor cells to generate MMPs. On the other hand, tumor cells had a capacity to fuse peripheral monocyte to be osteoclast-like giant cells. Through those interactions, bone destruction may be advance.

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] 南谷 和仁: "ヒト転移性腎癌の培養細胞樹立株において" 整形外科と災害外科. 39. 1699-1702 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 南谷 和仁: "横紋筋肉腫の培養細胞樹立株とそのゼラチナーゼ活性について" 中部日本整形外科災害外科学会雑誌. 34. 565-567 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 南谷 和仁: "骨肉腫細胞のコラゲナーゼ産生能について" 整形外科と災害外科. 39. 590-593 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 南谷 和仁: "培養骨肉腫細胞のmatrix metalloproteinase(MMP)活性と培養条件によるその変動について" 整形外科と災害外科. 41. 519-522 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuro KOMIYA: "The pathogenesis and etiology of giant cell tumor of bone from a viewpoint of bone resorptive factors" Nippon Seikeigeka Gakkai Zasshi. 66. 485-492 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuro KOMIYA,Kazuhito MINAMITANI: "Simple bone cyst Treatment by trepanation and studies on bone resorptive factor in cyst fluid with a theory of it′s pathogenesis" Clin.Orthop. 287. 204-211 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuro KOMIYA,Kazuhito MINAMITANI: "Cementation in the treatment of giant cell tumor of bone" Arch Orthop Trauma Surg.112. 51-55 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuro KOMIYA: "Aggressive bone tumorous lesion in infancy -Osteofibrous dysplasia of the tibia and fibula" J.Ped Orthop.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Setsuro Komiya: "The pathogenesis and etiology of giant cell tumor of bone from a viewpoint of bone resorptive factors" Nippon Seikeigeka Gakkai Zasshi. 66. 485-492 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Simple bone cyst Treatment by trepanation and studies on bone resorptive factor in cyst fluid with a theory of it's pathogenesis" Clin.Orthop. 287. 204-211 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuhito Minamitani Setsuro Komiya et al: "Secretion of matrix metalloproteinases by cells cultured from human osteosarcoma"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kazuhito Minamitani, Setsuro Komiya et al: "Effect of Culture Condition on Secretion of Matrix Metalloproteinases from Cultured Osteosarcoma Cells"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Osteoclast-like Multinucleated giant cells derived from peripherl monocytes by fusion"

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setsuro Komiya, Kazuhito Minamitani: "Cementation in the treatment of giant cell tumor of bone" Arch Orthop Trauma Surg. 112. 51-55 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setsuro Komiya: "Aggressive bone tumorous lesion in infancy -Osteofibrous dysplasia" J.Ped Orthop.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Setauro Komiya: "Establishment of osteosarucoma cell line with features of pre-and osteobrasts"

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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