1992 Fiscal Year Final Research Report Summary
Prophylactic effect of concomitant administration with verapamil and cimetidine on cisplatin-induced nephrotoxicity
| Project/Area Number |
02670712
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Urology
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| Research Institution | KYUSHU UNIVERSITY |
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Principal Investigator |
UEDA Toyofumi Kyushu University. Faculty of Medicine. Associate Professor, 医学部, 助教授 (20037401)
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| Co-Investigator(Kenkyū-buntansha) |
YASUMASU Tetsuo Kyushu University. Faculty of Medicine. Assistant, 医学部, 助手 (30166524)
UOZUMI Jiro Kyushu University. Faculty of Medicine. Lecturer, 医学部, 講師 (30223514)
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| Project Period (FY) |
1990 – 1992
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| Keywords | Cisplatin / Nephrotoxicity / Protection / Verapamil / Cimetidine / Methylpredonisolone / Antitumor effect |
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| Research Abstract |
The protective effects of the concomitant use of verapamil and cimetidine on nephrotoxicity of cisplatin were not observed. Calcium blocker enhanced the renal accumulation of Pt and the nephrotoxicity of cisplatin. The prophylactic effect of methylpredonisolone against cisplatin nephrotoxicity was confirmed. The pretreatment with methylpredonisolone 4 hours prior to cisplatin injection plays an important role in protecting the kidney from cisplatin toxicity. Methylpredonisolone did not inhibit the antitumor effects of cisplatin.
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