1991 Fiscal Year Final Research Report Summary
Studies of Experimental Oral Tumors Produced by Heterocyclic Amines in the Broiled Food
| Project/Area Number |
02670820
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Morphological basic dentistry
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| Research Institution | Aichi-Gakuin University |
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Principal Investigator |
KAMEYAMA Yoichiro Aichi-Gakuin University, Department of Pathology, Professor, 歯学部・病理学講座, 教授 (70113066)
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| Project Period (FY) |
1990 – 1991
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| Keywords | animal / tongue / gingiva / wound / heterocyclic amines |
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| Research Abstract |
Recently, many mutagenic compounds have been isolated from pyrolysates of amino acids and cooked foods. These mutagens are aromatic heterocyclic amines, and Trp-P-2, Glu-P-1, MeIQ, MeIQx and IQ are five of them. In this project, four experiments were performed. In the first experiment, the tongues of the hamsters were treated with Trp-P-2 or Glu-P-1 for 16 weeks, and then the tongues were wounded. These tongues did not show any marked epithelial dysplasias. In the second experiment, most of the tongues of the hamsters which were treated with Trp-P-2 or MeIQ for 4 weeks together with double woundings, showed epithelial dysplasias. In the third experiment, the tongues of the hamsters which were treated with Trp-P-2 or MelQx or IQ for 4 weeks in combination with double woundings, frequently showed epithelial dysplasias. In the forth experiment, the application of Glu-P-1 to the gingival wound in rats induced the marked ultrastructural changes in the epithelium-connective tissue junction, particularly the basal lamina.
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[Publications] Fujita, K., Itatsu, K., Suzuki, J., Sato, E., Maeda, H. and Kameyama, Y.: "Histological study on experimental dysplasia using aromatic heterocyclic amines (Trp-P-2, MeIQx, IQ)" J. Jpn. Stomatol. Soc.40. 499-506 (1991)
Description
「研究成果報告書概要(欧文)」より
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[Publications] Takesue, M., Fujita, K., Nonobe, K., Hara, M., Sato, E., Maeda, H. and Kameyama, Y.: "Effect of Glu-P-1 (2-amino-6-methyl dipyrido-[1, 2-a : 3', 2'-d]imidazole) on wound healing of the rat gingiva." J. Jpn. Stomatol. Soc.
Description
「研究成果報告書概要(欧文)」より
