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1991 Fiscal Year Final Research Report Summary

Evaluation of a Bone Substitute Prepared From alpha-Tricalcium Phosphate and an Acid Polysaccharide Solution

Research Project

Project/Area Number 02670891
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 外科・放射線系歯学
Research InstitutionNiigata University

Principal Investigator

NAGAMINE Takeshi  Niigata University, School of Dentistry Lecturer, 歯学部附属病院, 講師 (20126436)

Co-Investigator(Kenkyū-buntansha) SUZUKI Ichirou  Niigata University, School of Dentistry, Assistant, 歯学部, 助手 (80179192)
NAKAJIMA Tamio  Niigata University, School of Dentistry, Professor, 歯学部, 教授 (10014010)
Project Period (FY) 1990 – 1991
Keywordsalpha-TCP / bone / dextran / Hydroxyapatite / glycolic acid
Research Abstract

Tissue response to a readily consolidating material prepared by mixing alpha-tricalcium phosphate (alpha-TCP) powder with a glycolic acid dextran solution and to this consolidating material combined with particulate hydroxylapatite (HA) was studied after implantation in the subperiosteal space of the mandible in rabbits. Active new bone formation comparable to that seen on HA implants was observed around the two compounds. The newly formed bone was in direct contact with the HA as well as the readily consolidated material and little adverse effect resulting from the glycolic acid and dextran was observed. Because the readily consolidating material was firm and could be countoured into any shape during the process of consolidation, it may be quite useful sa a bone substitute and as an adherent for HA particles for reconstructive bone surgery, overcoming the disadvantages inherent to the particulate form of HA.

  • Research Products

    (2 results)

All Other

All Publications (2 results)

  • [Publications] Mamoru Nagase: "Evaluation of a Bone Substitute Prepared From α-Tricalcium Phosphate and an Acid Polysaccharide Solution" Journal of Oral and Maxillofacial Surgery. 49. 1305-1309 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] "Evaluation of a Bone Substitute Prepared From alpha-tricalcium Phosphate and Acid Polysaccharide Solution" Journal of Oral and Maxillofacial Surgery. 49. 1305-1309 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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