1991 Fiscal Year Final Research Report Summary
Bioinorganic Chemistry on Vanadium Complexes possessing Anti-diabetic Action
| Project/Area Number |
02670982
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Physical pharmacy
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| Research Institution | Kyoto Pharmaceutical University (1991)
The University of Tokushima (1990) |
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Principal Investigator |
SAKURAI Hiromu Kyoto pharmaceutical University, Faculty of Pharmaceutical Sciences Department of Analytical Chemistry Professor, 薬学部, 教授 (30065916)
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| Co-Investigator(Kenkyū-buntansha) |
TAKESHIMA Shigeo Kyoto Pharmaceutical University, Faculty of Pharmaceutical Sciences Department o, 薬学部, 助手 (60236461)
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| Project Period (FY) |
1990 – 1991
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| Keywords | insulin-like action / vanadyl compounds / diabetes / streptozotocin / blood glucose level / vanadyl-cysteine methyl ester / vanadium determination / adipocites |
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| Research Abstract |
We investigated whether vanadyl ion, which is less toxic than vanadate to rats, has an insulin-like effect in rats with streptozotocin (STZ) -induced diabetes. When rats with STZ -induced diabetes were given a daily i. p. injection of vanadyl sulfate or a daily p. o. admistration of vanadyl complexes like vanadyl-cysteine methyl ester (V-Cys), their blood glucose levels decreased to the normal level within 2 days and remained low for 12 weeks. These treatments did not affect their low plasma insulin levels. Quantitative electron spin resonance (ESR) spectrometry showed that most of the vanadium(-90%)in their tissues was present as a vanadyl form (VO^<2+>). Vanadium treatments accelerated glucose incorporation into adipocytes of rats suggesting that the action of vanadyl ion is peripheral. These results including that V-Cys showed anti-diabetic action when it was given orally, suggest that the vanadyl complexes are possible to use clinically to treat diabetes
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