1991 Fiscal Year Final Research Report Summary
Brain peptides : central regulation of the cardiovascular, renal and autonomic nervous functions in conscious rats
| Project/Area Number |
02807018
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
環境生理学(含体力医学･栄養生理学)
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| Research Institution | University of Occupational and Environmental Health |
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Principal Investigator |
KANNAN Hiroshi University of Occupational and environmental health, Dept. of Physiology, Associate Professor, 医学部, 助教授 (00049058)
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| Project Period (FY) |
1990 – 1991
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| Keywords | Conscious rats / Renal sympathetic nerve activity / Cardiovascular system / peptide / Angiotensin II / Atrial natriuretic polypeptide / Endothelin-3 / Interleukin-1 |
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| Research Abstract |
Effects of intracerebroventricular (i. c. v.) administration of peptides on cardiovascular function and renal sympathetic nerve activity (RSNA) were examined in conscious rats.
1)Angiotensin II (AII) elicited an increase in arterial blood pressure (AP) and decreases in heart rate (HR) and RSNA. The inhibitory response of RSNA persisted in sinoaorticdenervated (SAD) rats. Natriuretic response induced by i. c. v. AII was greatly attenuated after bilateral renal denervation. Since activation of RSNA increases tubular sodium absorption, the finding suggests that central AII has facilitatory effect on renal sodium excretion through the RSNA. Water intake induced by All was enhanced in SAD rats, compared to that in intact rats, suggesting involvement of baroreceptors in control of drinking behaviour.
2)Atrial natriuretic polypeptide (ANP) had no significant effects on resting AP, HR, RSNA and renal blood flow. Prior administration of ANP however, attenuated AII-induced pressor response. HR and RSNA responses induced by AII were not affected by the ANP.
3)Endothelin-3 (ET-3) elicited an increase in AP and decreases in HR and RSNA. ET-3 sometimes produced a barrel rotation with a latency of 10-15 min. At the time, prominent and long-lasting increases in HR and RSNA occurred.
4)Interleukin I (IL-1), a cytokine essentially produced by macrophage, has central actions such as fever and ACTH release. Effects of IL-1 on autonomic nervous system, which may play a critical role in the interaction between the immune system and the central nervous system, has not well elucidated. IL-1 increased AP, HR and RSNA followed by an increase in body temperature. The responses were completely abolished by indomethacin. IL-1 also increased plasm noradrenaline and ACTH concentrations.
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[Publications] Osaka,T.,Kannan,H,Kasai,M.,Inenaga,K,& Yamashita,H.: "Osmotic responses of rat paraventricular neurons by ejection method." Brain Res.,Bull.,. 24. 493-497 (1990)
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「研究成果報告書概要(和文)」より
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[Publications] Inenaga, K., Kannan, H., Yamashita, H., Tribollet, E., Raggenbass, M. & Dreifuss, J. J.: "Oxytocin excites neurons located in the ventromedial nucleus of the guinea-pig hypothalamus" J. Neuroendocrinology. 3. 569-573 (1991)
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「研究成果報告書概要(欧文)」より
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