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1991 Fiscal Year Final Research Report Summary

Effect of Magnesium Lithospermate B on Renal Circulatory State

Research Project

Project/Area Number 02807209
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 医学一般
Research InstitutionToyama Medical and Pharmaceutical University

Principal Investigator

YOKOZAWA Takako  Toyama Medical and Pharmaceutical University, Research Institute for Wakan-Yaku, Associate Professor, 和漢薬研究所, 助教授 (90019133)

Project Period (FY) 1990 – 1991
KeywordsMagnesium lithospermate B / Renal function / Prostaglandin E_2 / Kallikrein / Kinin / Blood pressure
Research Abstract

Studies on the mechanism of magnesium lithospermate B, which is a newly found constituent of Salviae Miltiorrhizae Radix, were performed. It was found that the renal function-faciltating action of magnesium lithospermate B was eliminated by indomethacin, suggesting that this compound acts on the prostaglandin system. Indeed, magnesium lithospermate B increased urinary excretions of prostaglandin E_2 (PGE_2) and 6-keto-prostaglandin F_<1alpha> (6-keto-PGF_<1alpha>). Furthermore, the effect of magnesium lithospermate B on the renal responses of rats with renal failure was investigated in the presence and absence of pretreatment with the kallikrein inhibitor, aprotinin. Pretreatment with aprotinin abolished the renal function-facilitating action of magnesium lithospermate B concomitantly with a markedly increased urinary excretion PGE_<2'> 6-keto-PGF_<1alpha> and kallikrein. In addition, the combination of magnesium lithospermate B and kininase II inhibitor, captopril, induced a further increase in renal function by improving the renal circulatory state. These results suggest that the kallikrein-kinin-prostaglandin system is involved in the renal responses elicited by magnesium lithospermate B.
We also evaluated the antihypertensive effect of magnesium lithospermate B in rats with sodium-induced hypertension and renal failure. It was found that administration of magnesium lithospermate B produced a significant reduction in blood pressure, accompanied by a significant increase of urinary sodium, PGE_2 and kallikrein excretions. The same results were demonstrated by the experiment using spontaneously hypertensive rats (SHR), Wistar-Kyoto rats (WKY) and deoxycorticosterone acetate (DOCA) rats.

  • Research Products

    (20 results)

All Other

All Publications (20 results)

  • [Publications] Takako Yokozawa: "Magnesium lithospermate B improves renal function via the kallikrei-prostaglandin system in rats with renal bailure" Jpn.J.Nephrol.32. 893-898 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal bailure" J.Nat.Prod.53. 662-665 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Renal responses to magnesium lithospermate B" J.Pharm.Pharmacol.42. 712-715 (1990)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Augmentation of Renal Responses by Magnesium Lithospermate B" Nephron. 57. 78-83 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Potentiationg Effect of Converting Enzyme Inhibitor Captopril to the Renal Responses of Magnesium Lithospermate B in Rats with Adenine-Induced" Chem.Pharm.Bull.39. 732-736 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Effect of Magnesium Lithospermate B in Rats with Sodium-induced Hypertesion and Renal Failure" Nephron. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Hemodynmic Effects of Magnesium Lithospermate B in Rats with Renal Failure" J.Phytotherapy Research. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Effect of magnesium lithospermate B on renal and urinary kallikrein activities in rats with adenine-induced renal failure" J.Ethne-Pharmacol.(1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Renal responses to magnesium lithospermate B in rats with adenine-induced renal failure" J.Ethne-Pharmacol.(1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 大浦 彦吉: "腎不全(尿毒症)" 代謝. 29臨時増刊号. (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Takako Yokozawa: "Magnesium lithospermate B improves renal function via the kallikrein-prostaglandin system in rats with renal failure" Jpn. J. Nephrol.32. 893-898 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Effect of magnesium lithospermate B on urinary prostaglandins in rats with renal failure" J. Nat. Prod.53. 662-665 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Renal responses to magnesium lithospermate B" J. Pharm. Phrmacol.42. 712-715 (1990)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Augmentation of Renal Responses by Magnesium Lithospermate B" Nephron. 57. 78-83 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Potentiating Effect of Converting Enzyme Inhibitor Captopril to the Renal Responses of Magnesium Lithospermate B in Rats with Adenine-Induced Renal Failure" Chem. Pharm. Bull.39. 732-736 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Effect of Magnesium Lithospermate B in Rats with Sodium-induced Hypertension and Renal Failure" Nephron.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Hemodynamic Effects of Magnesium Lithospermate B in Rats with Renal Failure" J. Phytotherapy Research.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Effect of magnesium lithospermate B on renal and urinary kallikrein activities in rats with adenine-induced renal failure" J. Ethno-Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Takako Yokozawa: "Renal responses to magnesium lithospermate B in rats with adenine-induced renal failure" J. Ethno-Pharmacol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hikokichi Oura: "Renal failure (uremia)" Metabolism and Disease.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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