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1991 Fiscal Year Final Research Report Summary

Integrative control of respiratory and circulatory functions with special reference to baro-and chemoreceptor activities.

Research Project

Project/Area Number 03044174
Research Category

Grant-in-Aid for Overseas Scientific Survey.

Allocation TypeSingle-year Grants
Research InstitutionChiba University

Principal Investigator

HONDA Yoshiyuki  Department of Physiology, School of Medicine, Chiba University, 医学部, 教授 (30019525)

Co-Investigator(Kenkyū-buntansha) BLAKEMORE Collin  University Laboratory of Physiology, University of Oxford, 所長
NYE Piers G.  University Laboratory of Physiology, University of Oxford, 講師
ROBBINS Peter A.  University Laboratory of Physiology, University of Oxford, 講師
SAITO Toshihiro  Department of Medicine, School of Medicine, Chiba University, 医学部, 講師 (40009593)
MASUDA Atsuko  Department of Physiology, School of Medicine, Chiba University, 医学部, 助手 (70165710)
SAKAKIBARA Yoshikazu  Kanazawa Institute of Technology, 教授 (50092060)
Project Period (FY) 1991
KeywordsBaroreceptors / Blood gas / Respiratory and circulatory activities / hypoxia / hypercapnia / brain blood flow
Research Abstract

Using a new apparatus to induce a stimulation for the carotid baroreceptors (Neck suction method), effect of alterations of blood gas levels on baroreceptor activities was investigated.
Four different blood gas conditions were used i. e., 1) hypoxia (alveolar Po2, 50 mmHg), 2) hyperoxia (alveolar Po2, 200 mmHg), 3) hypercapnia (alveolar Pco2, 5mmHg higher than the control) and 4) combination of 1) and 3).
For neck suction, three degrees of negative pressure were applied, i. e., 20, 40 and 60mm Hg. Thus, combination of above conditions made us 12 different experimental procedures.
Main findings obtained were as follows :
1. Effect of baroreceptor stimulation was dominantly seen during expiratory phase.
2. Carbon dioxide stimulation was found to be inhibitory in all experimental conditions.
3. Positive interaction was seen in the effect between hypoxia and hypercapnia.
4. Effect of neck suction attained to be saturated between 40 to 60 mmHg.
Sine the effect of hypoxia was not so marked as expected, brain blood flow was measured by using a laser Doppler method to elucidate the possible explanation. The time course to increase brain blood flow in response to hypoxia and hypercapnia was compared.
Since the grant to proceed this joint study was afforded at the very end of the fiscal year, the detailed analysis of the data is still in process.

  • Research Products

    (8 results)

All Other

All Publications (8 results)

  • [Publications] Sakakibara,Y.,A.Masuda,M.Chowdhury,M.Tanaka,T.Ohdaira,T.Kobayashi,and Y.Honda: "Effects of sustained hypoxia on the middle cerebral blood flow velocity responses to lower body negative pressure in man." In:4th international symposium on high-altitude medical science,Matsumoto,Japan.A guide for the 4th international symposium on high-altitude medical science.29 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakakibara,Y.,Y.Honda,P.A.Robbins,and D.H.Bergel: "Response of ventilation and blood flow velocity in the middle cerebral artery to sustained hypoxia and carbon dioxide in man." In:"1991 Oxford conference:5th meeting on control of breathing and its modelling perspective,Fuji Institute of Training,Japan"Abstracts. 93 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakakibara,Y.,B.Ahn,M.Tanaka,T.Kobayashi,T.Ohdaira,Y.Honda,and P.Robbins: "Ventilation and blood velocity responses of the middle cerebral artery to sustained hypoxia in man." Jpn.J.Physiol.41(Suppl.). s101 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 榊原 吉一,増田 敦子,M.Chowdhury,田中 美智子,大平 徹郎,小林 敏生,本田 良行: "下半身陰圧負荷に対する中大脳動脈の脳血流速度の反応" 第8回宇宙利用シンポジウム・日本学術会議 Proceedings of the eighth space utilization symposium. 175-180 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakaibara, Y., A. Masuda, M. Chowdhury, M. Tanaka, T. Ohdaira, T. Kobayashi and Y, Honda.: "Effect of sustained hypoxia on the middle cerebral blood flow velocity response to lower body negative pressure in man." 4th International symposium on high altitude medical science.29 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakaibara, Y., Y. Honda, P. A. Robbins and D. H. Burgel.: "Response of ventilation and blood floelocity in the middle cerebral artery to sustained hypoxia and carbon dioxide in man." 5th meeting on control of breathing and its modeling perspective.93 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakakibara, Y., B. Ahn, N. Tanaka, T. Kobayashi, T. Ohdaira, Y. Honda and P. Robbins.: "Ventilation and blood velocity response of the middle cerebral artery to sustained hypoxia in man." Jpn. J. Physiol.101 (41)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Sakakibara, Y., A. Masuda, M. Chowdhury, M. Tanaka, T. Ohdaira, T. Kobayashi and Y. Honda.: "Blood flow response of the middle cerebral artery in response to lower body negative pressure." 8th symposium for space science organized by Japanese Science Council. Proceedings of the eighth space utilization symposium.175-180 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1993-03-16  

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