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1992 Fiscal Year Final Research Report Summary

Analysis of marginal and apical periodontal diseases and their systemic effects

Research Project

Project/Area Number 03304043
Research Category

Grant-in-Aid for Co-operative Research (A)

Allocation TypeSingle-year Grants
Research Field Conservative dentistry
Research InstitutionTokyo Medical and Dental University

Principal Investigator

SUDA Hideaki  Tokyo Med. & Dent. Univ., Fac. Dent., Professor, 歯学部, 教授 (00114760)

Co-Investigator(Kenkyū-buntansha) NISHIKAWA Hirofumi  Meikai Univ., Sch. Dent., Professor, 歯学部, 教授 (90049388)
ISHIKAWA Isao  Tokyo Med. Dent. Univ., Fac. Dent., Professor, 歯学部, 教授 (10014151)
MURAYAMA Youji  Okayama Univ., Sch. Dent., Professor, 歯学部, 教授 (50029972)
NAKAMURA Jiro  Tsurumi Univ., Sch. Dent., Professor, 歯学部, 教授 (90064336)
OSADA Tamotsu  Kanagawa Dent. College, Professor, 教授 (70084720)
Project Period (FY) 1991 – 1992
KeywordsMarginal Periodontitis / Apical Periodontitis / Periodontal Tissues / Periodontopathic Bacteria / Immune Response / Immunocompetent Cells / LPS / Cytokine
Research Abstract

Suda investigated immunohistochemically the characteristics of defense reactions in experimentally-induced rat periapical lesion and examined the effects of neutropenia on the development of the lesion. Tanaka found the involvement of lipid peroxides in the development of periapical lesion. Kawanami observed using SEM that several bacteria were present at the outer root surface around the apical foramen. Kumagai investigated histologically the experimentally-induced endodontal-periodontal lesions in dogs. Yamaki showed that Ca(OH)_2 used as an intracanal medicament was effective for clinical use. Okamoto measured the release of several cytokines from monocytes after the challenge of LPS from periodontopathic bacteria. Ishikawa demonstrated the expression of adhesion molecules in periodontal lesions. J. Nakamura revealed that periapical tissue healing following root canal filling was stimulated by disocclusion. Osada investigated some biological properties of fibroblasts cultured from p … More eriapical granulomas. Nishikawa found that the measurement of impulse-response of periodontium to tooth percussion was applicable for the diagnosis of the diseased conditions of periodontium. H. Nakamura investigated the effects of LPS from intracanal bacteria on cultured pulpal cells, periodontal ligament cells and calvarial cells. Kimura revealed that some adult periodontitis patients showed lower responses in autologous mixed lymphocyte reaction. Yoshikawa investigated immunohistochemically the distribution of macrophages in rat periapical granulomas. Murayama found that the population density of black-pigmented anaerobic rods in periodontal pocket varied from site to site and that there was DNA polymorphism of P. gingivalis even in a single pocket. Matsuo analyzed the correlations between the number of immunocompetent cells in periapical lesions and the clinical findings of the involved teeth. Maeda demonstrated the presence of IL-1beta mRNA-expressing cells in experimentally-induced periapical lesion using in situ hybridization. Yokota investigated the effects of sympathetic nerves on the periodontal tissue. Less

  • Research Products

    (48 results)

All Other

All Publications (48 results)

  • [Publications] OKIJI,T.: "An immunohistochemical study of the distribution of immunocompetent cells,especially macrophages and la antigen-expressing cells of heterogeneous populations,in normal rat molar pulp." Journal of Dental Research. 71. 1196-1202 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKIJI,T.: "Pathophysiological roles of arachidonic acid metabolites in rat dental pulp" Proceedings of the Finnish Dental Society. 88. 433-438 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKIJI,T.: "Immunohistochemical detection of prostagland in I^2 synthase in various calcified tissue-forming cells in rat" Archives of Oral Biology. 38. 31-36 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKIJI,T.: "Distribution of la antigen-expressing non-lymphoid cells in various stages of induced periapical lesions in rat molars" Journal of Endodontics.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小坂 俊彦: "ラット臼歯発育過程における歯髄内免疫担当細胞の変動" 日本歯科保存学雑誌. 35. 1474-1480 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小坂 俊彦: "歯髄および根尖歯周組織における早期防衛反応に関する免疫組織化学的研究" 日本歯科保存学雑誌. 36. 92-108 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKUMURA,Y.: "The study of mechanical properties on the periodontium" Japanese Journal of Oral Diagnosis and Oral Medicine. 5. 251-258 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小林 健二: "歯の槌打による歯周組織の衝撃応答に関する研究" 日本歯科保存学雑誌. 36. 206-224 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 木村 重信: "成人性歯周炎患者における自己リンパ球混合培養反応の検討" 炎症. 11. 489-494 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KIMURA,S.: "Impaired autologous mixed-lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis" Infection and Immunity. 59. 4418-4424 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 野津 眞一郎: "背部皮下肉芽嚢の成因から見た歯根肉芽腫の成立機転" 日本歯科保存学雑誌. 35. 701-719 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 高橋 慶壮: "抗体産生関連リンパ球諸機能の歯周病病態への関わりの研究" 日本歯周病学会会誌. 33. 685-694 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 八巻 恵子: "水酸化カルシウム貼薬による歯根周囲のpH変化と臨床応用に関する研究" 日本歯科保存学雑誌. 36. 147-157 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鎌形 有祐: "歯周病原細菌内毒素のインターロイキン6,腫瘍壊因子α,インターロイキン1βの産生誘導能" 日本歯科保存学雑誌.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] NAGASAWA,T.: "Negative selection of thymus-dependent CD4^+8^+ intestinal intraepithelial lymphocytes by internal superantigens" Cellular Immunology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] YASUI,S.: "Rapid identification of Porphyromonas gingivalis by bisulfite-modified DNA probe method" Journal of Periodontal Research.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] NITTA,H.: "Analysis of the genetic control of antibody response to Actinobacillus actinomycetemcomitans by immunoblotting in inbred strains of mice" Oral Microbiology and Immunology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 鈴木 二郎: "根管処置前後の歯根肉芽腫由来線維芽細胞様細胞の動態" 神奈川歯学.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 後藤 弘幸: "重度の歯周炎を有する4人家族の症例研究ー宿主防御機能を中心にー" 日本歯科保存学雑誌. 34. 1699-1709 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KURIHARA,H.: "Humoral immune response to an antigen from Porphyromonas gingivalis 381 in periodontal deseases" Infection and Immunity. 59. 2758-2762 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 千原 敏裕: "早配発症型歯周炎を発現する一家族の宿主細胞機能所見" 日本歯周病学会会報. 34. 204-212 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 滝川 雅之: "ヒト歯肉線維芽細胞の機能に及ぼすインターロイキン1βの形響" 日本歯科保存学雑誌. 35. 554-563 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MATSUO,T.: "Quantitative analysis of immunocompetent cells in human periapical lesions: correlations with clinical findings of the involved teeth" Journal of Endodontics. 18. 497-500 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] ANAN,H.: "A histochemical study of bone remodeling during experimental apical periodontitis in rats" Journal of Endodontics. 17. 332-337 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] ANAN,H.: "An enzyme histochemical study of the behavior of rat bone cells during experimentalapical periodontitis" Journal of Endodontics. 19. 83-86 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] OKIJI, T.: "An immunohistochemical study of the distribution of immuno- competent cells, especially macrophages and Ia antigen- expressing cells of heterogeneous populations, in normal rat molar pulp." J. Dent. Res.71. 1196-1202 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OKIJI, T.: "Pathophysiological roles of arachidonic acid metabolites in rat dental pulp." Proc. Finn. Dent. Soc.88 (Suppl. 1). 433-438 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OKIJI, T.: "Immunohistochemical detection of prostaglandin I2 synthase in various kinds of calcified tissue-forming cells in rat." Arch. Oral Biol.38. 31-36 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OKIJI, T.: "Distribution of Ia antigen-expressing non-lymphoid cells in various stages of induced periapical lesions in rat molars." J. Endodon.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KOSAKA, T.: "Changes in the distribution of various immunocompetent cells in rat molar pulp during tooth development." Japan. J. Cons. Dent. 35. 1474-1480 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KOSAKA, T.: "Early pulpal and periapical tissue reactions after pulp exposure -an immunohistochemical study-" Japan. J. Cons. Dent.36. 92-108 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YAMAKI, K.: "The effect of calcium hydroxyde dressing on pH around roots and its clinical application." Japan. J. Cons. Dent.36. 147-157 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NAGASAWA, T.: "Negative selection of thymus-dependent CD4+CD8+ intestinal intraepitherial lymphocytes by internal superantigens." Cell. Immunol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] YASUI, S.: "Rapid identification of Porphyromonas gingivalis by bisulfite-modified DNA probe method." J. Periododont. Res.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NITTA, H.: "Analysis of the genetic control of antibody response to Actinobacillus actinomycetemcomitans by immunoblotting in inbred strains of mice." Oral Microbiol. Immunol.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] OKUMURA, Y.: "The study of mechanical properties on the periodontium." Japan. J. Oral Diag. Oral Med.5. 251-258 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KOBAYASHI, K.: "Studies on the impulse-response of periodontium to tooth percussion." Japan. J. Cons. Dent. 36. 206-224 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KIMURA, S.: "Autologous mixed lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis." Japan. J. Inflammation. 11. 489-494 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KIMURA, S.: "Impaired autologous mixed lymphocyte reaction of peripheral blood lymphocytes in adult periodontitis." Infect. Immun.59. 4418-4424 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] NOZU, S.: "Potencies of several factors in granuloma pouch formation and their participation in periapical granuloma formation in rats." Japan. J. Cons. Dent.35. 701-719 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] TAKAHASHI, K.: "Studies on the status of periodontal disease from the lymphocytes functions concerned with immunoglobulin synthesis." J. Japan. Ass. Periodont.33. 685-694 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] GOTO, H.: "A case study in single family manifesting severe periodontitis -analysis of factors concerned with host defense-" Japan. J. Cons. Dent.34. 1699-1709 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] KURIHARA, H.: "Humoral immune response to an antigen from Porphiromonas gingivalis 381 in periodontal diseases." Infect. Immun.59. 2758-2762 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] CHIHARA, T.: "Host defense findings in a single family manifesting early-onset periodontitis." J. Japan. Ass. Periodont.34. 204-212 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] TAKIGAWA, M.: "The effects of interleukin 1bata on function of human gingival fibroblasts." Japan. J. Cons. Dent.35. 554-563 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] MATSUO, T.: "Quantitative analysis of immunocompetent cells in human periapical lesions: correrations with clinical findings of the involved teeth." J. Endodon.18. 497-500 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] ANAN, H.: "A histochemical study of bone remodeling during experimental apical periodontitis in rats." J. Endodon.17. 332-337 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] ANAN, H.: "An enzyme histochemical study of the behavior of rat bone cells during experimental apical periodontitis." J. Endodon.19. 83-86 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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