1993 Fiscal Year Final Research Report Summary
Co-operative Responses of Organella Constituents to Drug stimulation
| Project/Area Number |
03304045
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| Research Category |
Grant-in-Aid for Co-operative Research (A)
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| Allocation Type | Single-year Grants |
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| Research Field |
Biological pharmacy
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| Research Institution | Kanazawa University |
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Principal Investigator |
OHBA Yoshiki Kanazawa University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (10012634)
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| Co-Investigator(Kenkyū-buntansha) |
ICHIKAWA Atsushi Kyoto University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (10025695)
ISHIBASHI Sadahiko Hiroshima University, School of Medicine Professor, 医学部, 教授 (90012616)
OKAMOTO Hiroshi Tohoku University, School of Medicine Professor, 医学部, 教授 (60025632)
NOMURA Yasuyuki Hokkaido University, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (00034041)
NATORI Shunji Unversity of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (50012662)
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| Project Period (FY) |
1991 – 1993
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| Keywords | organella constituents / drugs / receptors / cell membrane / cytoplasm / cell nucleus / transduction / gene regulation / G protein |
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| Research Abstract |
On considering the efficiency for promoting our project research, this research group was divided into three subgroups depending on the idea that organella consisting domain can be classified to cell membrance, cytoplasm and cell nucleus.
(1)The interaction of functional molecules in cell membrane and expression of 2nd messenger with cytosolic factors : the biosynthesis of phospholipid (Akamatsu) and chlesterol (Inoue) and their transport to cell membrance. (2)The active bahavior of functional molecules in cytoplasmic organella : effect of anti-trypanozoma drug to peroxisome formation (Takano), interaction of G protein with mast cells (Ichikawa) and serotonin receptor (Nomura), effects of polyamines to ribosomal function (Igarashi), and contribution of cyclic ADP ribose (Okamoto).(3)The effect of exogenous stimulant to nuclear functional molecules and the response : regulation of gene expression for the response to thyroid (Ohba), steriod (Noda) and glucagon (Ichiyama) hormone stimulation contribution of G protein to the formation of nuclear membrane (Natori)..13EA03 : In the research meeting we discussed on basis of each own result about the processes how exogenous information is converted to 2nd messenger through transduction mechanism and finally attain to the target gene. We concluded that there should be enormous ways of information transfer from cell surface receptor to the target gene, among which contribution of cyclic ADP ribose, discovered by Okamotao must be very important. The further research should be conncentrated to the point that how the steady state passway of information transfer can be disturbed by the foreign information, that is newly administered drugs or inhibitors. These observations may offer many suggestions to the analysis of drug action.
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