1993 Fiscal Year Final Research Report Summary
MECHANISM OF MAINTENANCE OF POTASSIUM HOMEOSTASIS IN NERVOUS SYSTEM BY GLIAL-NEURONAL INTERACTION
| Project/Area Number |
03454131
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | INSTITUTE FOR ENZYME RESEARCH |
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Principal Investigator |
INOUE Isao 徳島大学, 酵素科学研究センター, 助教授 (80001973)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Potassium ion / Homeostasis / Glial-neuronal interaction / Squid giant axon / Isolation / Schwann cell / Calcium channel / Calcium activated / Potassium channel |
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| Research Abstract |
The K^+ homeostasis was found to be maintained at least three processes. The fast and medium processed were revealed to be due to lateral diffusion and transversal diffusion through microtubular system across the Schwann cell, respectively from the electrophysiological and electron microscopic studies. The slow process was found to be related to ionic mechanism of the Schwann cell by whole cell-patch clamp studies on enzymatically isolated Schwann cells. We found at least three voltage sensitive currents ; inward Ca^<2+> -sensitive outward K^+ current, and inwardly rectifying current that appeared at hyperpolarizing voltages.
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[Publications] Fuhino, K., Nakya, S., Wakatsuki, Y., Miyoshi, Y., Nakaya, Y., Mori, H., and Inoue, I.: "Effect of nitroglycerin on ATP-induced Ca^<2+> mobilization, Ca^<2+> activated K channels and contraction in cultured smooth muscle cells of porcine coroyany artery" J.Pharmacol.Exp.Ther.256. 371-377 (1991)
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[Publications] Miyoshi, Y., Nakaya, Y., Wakatsuki, T., Nakaya, S., Saito, K., Fujino, K., and Inoue, I.: "Endothelin blocks ATP-sensitive K^+ channel and depolarizes smooth muscle cells of porcine coronary artery" Circulation Res.70. 612-616 (1992)
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[Publications] Beauvais, F., Shimahara, T., Inoue, I., Hieblot, C., Burtin, C.and Benveniste, J.: "Regulation of human basophil activation II.Histamine release is potentiated by K^+ efflux and inhibited by Na^+ influx" J.Immunol.148. 149-154 (1992)
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[Publications] Kishimoto, U., Inoue, I., Tsutsui, I., and Ohkawa, T.: Voltage dependence of the ouabain-sensitive current of the squid axon membrane. in "Cephalopod Neurobiology" (Ed. Abbott, N.J., Williamson, R.and Maddok, L.) Oxford University Press (in press),
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[Publications] Pichon, Y., Abbott, N.J., Inoue, I., Brown, E.R., and Revest, P.A.: Periaxonal K^+ accumulation and regulation in the squid. in "Cephalopod Neurobiology" (Ed. Abbott, N.J., Williamson, R.and Maddok, L.) Oxford University Press (in press),
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