1993 Fiscal Year Final Research Report Summary
Regulation of cardiovascular function by novel peptidergic vasodilator nerves
| Project/Area Number |
03454143
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | University of Tsukuba |
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Principal Investigator |
GOTO Katsutoshi Pharmacol., Inst.Basic Med.Sci., Univ.Tsukuba Prof., 基礎医学系, 教授 (30012660)
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| Co-Investigator(Kenkyū-buntansha) |
KASUYA Yoshitoshi Pharmacol., Inst.Basic Med.Sci., Univ.Tsukuba Lect., 基礎医学系, 講師 (70221877)
SAITO Akira Pharmacol., Inst.Basic Med.Sci., Univ.Tsukuba Lect., 基礎医学系, 講師 (40137708)
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| Project Period (FY) |
1991 – 1993
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| Keywords | vasodilation / hypertension / mesenteric artery / endothelium / heart / microcirculation / CGRP / endothelin-1 |
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| Research Abstract |
It has been known that the cardiovascular function is controlled by classical autonomic nerves and humoral factors. Recently, additional regulatory system of cardiovascular function, including endothelium-derived factors, novel peripheral nerves, etc., has been postulated. We have demonstrated in isolated cardiac tissues and mesenteric vasculature that there exist novel cardiostimulatory and vasodilatory nerves the neurothransmitter of which is calcitonin gene-related peptide (CGRP). In the present study, it was shown that the density of CGRPergic vasodilatory nerves around mesenteric arteries decreased along with the increase in age in only spontaneously hypertensive rats but not in control (Wistar Kyoto) rats. This change may contribute to the maintenance of or the progress in severeness of the hypertension. In microcirculatory system of the heart, skeletal muscle or gastric mucuos membrane, endothelin-1 caused potent and long-lasting vasoconstriction. When CGRPergic nerves were degenerated by means of capsaicin treatment, endothelin-1-induced vasoconstriction was markedly potentiated, implying that a compensatory vasodilation may be operated by CGRPergic nerves in physiological conditions. In the analysis of vasodilation during post-tetanic hyperaemia in skeletal muscle, some experimental evidences have been obtained which suggest that CGRP is also concerned with the hyperaemia.
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[Publications] Miyauchi, T., Yorikane, R., Sakai, S., Sakurai, T., Okada, M., Nishikibe, M., Yano, M., Yamaguchi, I., Sugishita, Y.and Goto, K.: "Contribution of endogenous endothelin-1 to the progression of cardiopulmonary alterations in rats with monocrotaline-induced pulmonary hypertension." Circ.Res.73. 887-897 (1993)
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「研究成果報告書概要(欧文)」より
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[Publications] Lazaratos, S., Kashimura, H., Nakahara, A., Fukutomi, H., Osuga, T., Urushidani, T., Miyauchi, T., and Goto, K.: "Gastric ulcer induced by submucosal injection of ET-1 : role of potent vasoconstriction and intraluminal acid." Am.J.Physiol.265. G491-G498 (1993)
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[Publications] Homma, S., Miyauchi, T., Sugishita, Y., Goto, K., Sato, M.and Ohshima, N.: "Vasoconstrictor effects of endothelin-1 on myocardium microcirculation studied by the langendorff perfusion method : differential sensitivities among microvessels." Microvasc.Res.43. 205-217 (1992)
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[Publications] Homma, S., Nagai, Y., Saito, M., Miyauchi, T., Sugishita, Y., Goto, K., Yamatsu, I,Sato, M.and Ohshima, N.: "Involvement of coronary microcirculation in the myocardial ischemia observed in the beating hearts of rats." Microcirc.Annual.8. 91-92 (1992)
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[Publications] Homma, S., Miyauchi, T., Sugishita, Y., Goto, K., Ookawa, K., Sato, M.and Ohshima, N.: "Effects of calcitonin gene-related peptide on coronary microcirculation" Microcirc.Annual.1991. 111-112 (1991)
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