| Project/Area Number |
03454177
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Experimental pathology
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| Research Institution | Kansai Medical University |
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Principal Investigator |
IKEHARA Susumu Kansai Medical University, 医学部, 教授 (90108986)
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| Co-Investigator(Kenkyū-buntansha) |
HISHA Hiroko Kansai Medical University, 医学部, 助手 (90151422)
TOKI Junko Kansai Medical University, 医学部, 助手 (40077681)
NAGATA Norikazu Kansai Medical University, 医学部, 講師 (40155940)
YASUMIZU Ryoji Kansai Medical University, 医学部, 講師 (00142753)
INABA Muneo Kansai Medical University, 医学部, 講師 (70115947)
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| Project Period (FY) |
1991 – 1993
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| Keywords | bone marrow transplantation / autoimmune diseases / hemopoietic stem cells / stromal cells / diabetes mellitus / chr glomerulonephritis / portal vein tolerance / animal models |
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| Research Abstract |
i) Bone marrow transplantation (BMT) plus bone grafts (to recruit donor-derived stromal cells) can prevent graft failure and autoimmune diseases in MRL/lpr mice.
ii) BMT can be used to treat not only a certain type of non-insulin-dependent diabetes mellitus but also its complications such as hyperlipidemia and diabetic nephropathy.
iii) Focal segmental glomerular sclerosis (FGS) is a stem cell disorders, and BMT can be used to treat FGS.
iv) Bone marrow stromal cells produce a new factor that attracts hemopoietic stem cells.
v) Hemopoietic stem cells trapped in the liver play a crucial role in the induction and maintainance of portal vein tolerance.
vi) We have established a new method for purifying pluripotent hemopoietic stem cells.
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