1992 Fiscal Year Final Research Report Summary
EPIDEMIOLOGICAL STUDIES ON ETIOLOGY OF LIVER FUNCTION TEST ABNORMALITIES IN WORKERS -SPECIAL REFERENCE TO HEPATITIS VIRUS TYPE C INFECTION
| Project/Area Number |
03454212
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
公衆衛生学
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| Research Institution | TOKAI UNIVERSITY (1992)
Keio University (1991) |
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Principal Investigator |
OKAZAKI Isao TOKAI UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF COMMUNITY HEALTH, PROFESSOR, 医学部, 教授 (00051649)
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| Co-Investigator(Kenkyū-buntansha) |
OSAKA Fumio TOKAI UNIVERSITY SCHOOL OF MEDICINE DEPARTMENT OF COMMUNITY HEALTH, ASSISTANT PR, 医学部, 講師 (70096204)
YOSIDA Katsumi KEIO GIJUKU UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PUBLIC HEALTH, ASSOCIAT, 医学部, 助教授 (80158435)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Industrial health / HCV infection / Liver disease / 健康管理 / C100-3抗体 |
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| Research Abstract |
In order to investigate the etiology of the abnormalities in liver function tests among workers, 800 workers in some workplace were extensively examined. It revealed that Hepatitis B virus (HBV) carrier 7%, Hepatitis C virus antibody (c100-3 antibody) positive 11%, alcoholic liver diseases 19%, marked obesity 30%, moderate alochol drink and/or moderate obesity 34% and unknown 1% were observed in workers who showed the abnormal liver function tests but the normal daily activity of both works and usual life. 350 workers in another workplace who received the pre-retirement health check revealed that 10% of workers with abnormal liver function tests had the positive antibody against HCV, and that workers without abnormal liver function tests showed negative except few. Therefore, the indication of C100-3 test should be for workers with liver function tests. The next problem is the role of HCV infection among workers with alcoholic liver diseases at the workplace. They were very different from the patients with alcoholic liver diseases in Kurihama National Hospital. The latter revealed that the HCV infection caused alcoholic liver diseases to severer state. But the former workers were not severe be-cause their drinking habit changed to a good improvement.
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