1993 Fiscal Year Final Research Report Summary
Clinical Significance of Brain Natriuretic Peptide (BNP) in Cardiac Diseases
| Project/Area Number |
03454218
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
内科学一般
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
MARUMO Fumitaki Tokyo Med. & Dent. Univ., Dept. Med., Professor, 医学部, 教授 (00050443)
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| Co-Investigator(Kenkyū-buntansha) |
HIROE M Tokyo Med. & Dent. Univ., Dept. Med., Assistant Professor, 医学部, 講師 (80101872)
HIRATA Y Tokyo Med. & Dent. Univ., Dept. Med., Associate Professor, 医学部, 助教授 (50135787)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Brain natriuretic peptide / Atrial natriuretic peptide / Congestive heart failure / Myocardial infarction |
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| Research Abstract |
The objective of the present investigation was to clarify the clinical significance of brain natriuretic peptide (BNP) in various cardiac diseases compared to that of atrial natriuretic peptide (ANP). Plasma BNP levels in normal subjects were 2-4pg/ml, which were one-fifth those of ANP.However, under pathological conditions, such as hypertension, chrome renal failure, congestive heart distress syndrome, plasma BNP levels were remarkably elevated which exceeded those of ANP.Plasma BNP levels showed prognostic marker for cardiac deseases. While plasma ANP was derived from atria, plasma BNP was it is concluded that BNP is exclusively secreted from ventricle in response to acute stress. Which may function as one of the cardiac compensatory mechanisms to reduce both pre-and after load under the pathological states.
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