1993 Fiscal Year Annual Research Report

パーキンソン病における髄液中の各種神経伝達物質の変化とその臨床的意義

Research Project

Project/Area Number	03454243
Research Institution	Iwata Medical University
Principal Investigator	東儀英夫岩手医科大学, 医学部, 教授 (90155490)
Co-Investigator(Kenkyū-buntansha)	高橋智岩手医科大学, 医学部, 講師 (50216719) 阿部隆志岩手医科大学, 医学部, 講師 (30202667)
Keywords	Parkinson's disease / Serotonin / Kynurenine
Research Abstract	パーキンソン病では、ドパミン系ニューロンのほかセロトニン系ニューロンの変性も報告されている。我々はパーキンソン病患者の髄液セロトニンおよびその関連物質を測定しドパミン系物質の変化、パーキンソン病の重症度、認知機能の低下などとの関係を検討した。 1)未治療のパーキンソン病患者では、総(有意型および抱合型)セロトニン、5-hydroxytryptophan,kynurenineおよび3-hydroxykynurenineの濃度が対照例と比較してパーキンソン病患者で有意に減少していた。総セロトニン濃度の減少はHoehn and Yahrの重症度(-0.74、p=0.004)、固縮(r=-0.67、p=0.010)、無動(r=-0.65、r=0.013)、すくみ足(r=-0.72、r=0.005)、の重症度と有意の負の相関が認められ、すくみ足との相関が特に高かった。 2)未治療のパーキンソン病患者では髄液ドパミン濃度も低下しており、セトニン濃度と有意な正の相関を示した。対照例では、むしろ負の相関傾向を示した。 3)L-dopa治療中の患者ではドパミン濃度が著しく上昇し、セロトニン濃度は、未治療例よりも更に低下していた。トリプトファン、5-HIAA、3-hydroxykynurenineはL-dopa投与と正の相関を示した。セロトニン濃度の低下は、痴呆スケールの低下と有意の相関を示した(r=0.93、p<0.0001)。

Research Products

(9 results)

All Other

All Publications (9 results)

[Publications] Tohgi H: "A slgnificant reduction of putative transmitter aminc in cerebrospinal fluid of patients with Parkinson's disease and spinocerbellar degenration." Neurosci,Lett. 126. 155-158 (1991)
[Publications] Tohgi H: "Concentrations of tyrosine.L-dihydroxphenylalanine,dopamine,and 3-0-methyldopa in the cerebrospinal fluid of Parkinson's disease" Neurosci.Lett. 127. 212-214 (1991)
[Publications] Tohgi H: "The significance of 3-0-methyldopa concentrations in the cerebrospinal gluid in the pathogensis of wearing-off phenomenon in Parkinson's disease." Neurosci.Lett. 132. 19-22 (1991)
[Publications] Tohgi H: "Monoamine,metabolism in the cerebrospinal fluid in Parkinson's disease:Relationship to clinical symptome and subsequent the rapeutic outcmes." J.Neural Transm[P-D Sact]. 5. 17-26 (1993)
[Publications] Tohgi H: "The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations parkinsonlan patients." J.Neural Transm [R-D Sect]. 5. 27-34 (1993)
[Publications] Tohgi H: "The effect of age on the concentrations of monoamines,amino acids,and their related;substances in the cerebrospinal fluid." J.Neural Transm[P-D Sect]. 5. 215-226 (1993)
[Publications] Tohgi H: "Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms." Neurosci,Lett. 150. 71-74 (1993)
[Publications] Tohgi H: "Alterations in the concentration of serotonergic and dopaminergic substances in,the cerebrospunal fluid changes after L-dona aoministration." Neurosci,Lett. 159. 135-138 (1993)
[Publications] Tohgi H: "The urate and xannthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type,Alzheimer type dementia,and Parkinson's disease." J,Neural Transm[P-D Sect]. (1993)

1993 Fiscal Year Annual Research Report

パーキンソン病における髄液中の各種神経伝達物質の変化とその臨床的意義

Principal Investigator

東儀 英夫 岩手医科大学, 医学部, 教授 (90155490)

Research Products

[Publications] Tohgi H: "A slgnificant reduction of putative transmitter aminc in cerebrospinal fluid of patients with Parkinson's disease and spinocerbellar degenration." Neurosci,Lett. 126. 155-158 (1991)

[Publications] Tohgi H: "Concentrations of tyrosine.L-dihydroxphenylalanine,dopamine,and 3-0-methyldopa in the cerebrospinal fluid of Parkinson's disease" Neurosci.Lett. 127. 212-214 (1991)

[Publications] Tohgi H: "The significance of 3-0-methyldopa concentrations in the cerebrospinal gluid in the pathogensis of wearing-off phenomenon in Parkinson's disease." Neurosci.Lett. 132. 19-22 (1991)

[Publications] Tohgi H: "Monoamine,metabolism in the cerebrospinal fluid in Parkinson's disease:Relationship to clinical symptome and subsequent the rapeutic outcmes." J.Neural Transm[P-D Sact]. 5. 17-26 (1993)

[Publications] Tohgi H: "The effects of L-threo-3,4-dihydroxyphenylserine on the total norepinephrine and dopamine concentrations parkinsonlan patients." J.Neural Transm [R-D Sect]. 5. 27-34 (1993)

[Publications] Tohgi H: "The effect of age on the concentrations of monoamines,amino acids,and their related;substances in the cerebrospinal fluid." J.Neural Transm[P-D Sect]. 5. 215-226 (1993)

[Publications] Tohgi H: "Concentrations of serotonin and its related substances in the cerebrospinal fluid of Parkinsonian patients and their relations to the severity of symptoms." Neurosci,Lett. 150. 71-74 (1993)

[Publications] Tohgi H: "Alterations in the concentration of serotonergic and dopaminergic substances in,the cerebrospunal fluid changes after L-dona aoministration." Neurosci,Lett. 159. 135-138 (1993)

[Publications] Tohgi H: "The urate and xannthine concentrations in the cerebrospinal fluid in patients with vascular dementia of the Binswanger type,Alzheimer type dementia,and Parkinson's disease." J,Neural Transm[P-D Sect]. (1993)

東儀英夫岩手医科大学, 医学部, 教授 (90155490)