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1992 Fiscal Year Final Research Report Summary

Analysis of coronary slosh phenomenon under coronary stenosis by measurement of blood flow or vasucular diameter in intramyocardial vessels and microvessels

Research Project

Project/Area Number 03454259
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Circulatory organs internal medicine
Research InstitutionKawasaki Medical School

Principal Investigator

KAJIYA Fumihiko  Kawasaki Medical School, Medical Engineering, Professor, 医学部, 教授 (70029114)

Co-Investigator(Kenkyū-buntansha) NINOMIYA Ishio  National Cardiovascular Center, Physiology, Director, 部長 (80033976)
OGASAWARA Yasuo  Kawasaki Medical School, Medical Engineering, Assistant Professor, 医学部, 講師 (10152365)
TSUJIOKA Katsuhiko  Kawasaki Medical School, Medical Engineering, Associate Professor, 医学部, 助教授 (30163801)
FUJIWARA Takashi  Kawasaki Medical School, Thoracic Surgery, Professor, 医学部, 教授 (90090224)
Project Period (FY) 1991 – 1992
KeywordsMyocardial ischemia / Intramyocardial coronary artery flow / Slosh phenomenon / Coronary artery stenosis / Sympathetic nerve system / Vasodilator / Coronary microvessels
Research Abstract

It is well known that myocardial ischemia is frequently observed in the subendocardial layer. Although several possible reasons have been claimed in relation to some characteristic differences between subendo- and subepi-cardial layers such as stress during systole, extravascular pressure, number density of blood vessels, and hematocrit, no conclusive reason is given yet. We have found that part of blood which flows into the subendocardial myocardium during diastole is forced to flow into the subepicardial artery by myocardial compression during systole and this reversed blood flow volume is an important determinant of transmural distribution. Prof. Feigl from University of Washington also predicted the possibility of blood transport from subendo- to subepi-cardial sides during systole. He then named this phenomenon "slosh" and has claimed its patho-physiological significance.
The objectives of this study are (1) to examine the effect of vasodilating compounds and sympathetic nerve syst … More em on the blood transport (slosh) from subendo- to subepi-cardial sides by myocardial compression during systole and the change in this effect in the case of coronary artery stenosis and (2) to study if these compounds can allow uniform blood distribution (anti-slosh hypothesis). The blood flow in septal artery of anesthetized open-chest dog was measured using a 20 MHz ultrasound Doppler velocimeter, and the extent of "slosh" was evaluated as the ratio of forward to backward flows. The effect of "slosh" was augmented by an increase in coronary artery stenosis and by administrations of adenosine or nitroglycerin into a coronary artery. It was found that the stimulation of alpha-sympathetic nerve system led to an anti-slosh effect which was linearly associated with heart rate. We also observed coronary microvessels in the subendocardial myocardium using a needle-probe CCD microscope and found that the arterial diameter decreased about 20 % during systole. This decrease in arterial diameter is considered to cause the "slosh" phenomenon. Less

  • Research Products

    (16 results)

All Other

All Publications (16 results)

  • [Publications] Fumihiko Kajiya, et al: "Blood Velocity Patterns in Poststenotic Regions and Velocity Waveforms for Myocardial Inflow Associated with Coronary Artery Stenosis in Dog" Transactions of ASME Journal of Biomechanical Engineering. 114. 385-390 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akihiro Kimura, et al: "Effect of Coronary Stenosis on Phasic Pattern of Septal Artery in Dog" American Journal of Physiology. 262. H1690-H1698 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Osamu Hiramatsu, et al: "Phasic Characteristics of Arterial Inflow and Venous Outflow of Right Ventricular Myocardium in Dog" American Journal of Physiology. 262. H1422-H1427 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Akihiro Kimura, et al: "Atrial contractility affects phasic blood flow velocity of atrial small vessels in the dog" Cardiovascular Research. 26. 1219-1225 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Masami Goto, et al: "Effect of Intracoronary Nitroglycerin Administration on Phasic Pattern and Transmural Distribution of Flow during Coronary Artery Stenosis" Circulation. 85. 2296-2304 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinichiro Tadaoka, et al: "Effect of Left Ventricular Hypertrophy Secondary to Systematic Hyperstension of Left Coronary Artery Flow Dinamics" Cardiovascular Research. 25. 955-964 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya: "Coronary Circulation in Physiological and Pathophysiological States" Springer-Verlag, 19 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya, et al: "Regulation of Coronary Blood Flow" Springer-Verlag, 13 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fumihiko Kajiya, et al: "Blood Velocity Patterns in Poststenotic Regions and Velocity Waveforms for Myocardial Inflow Associated with Coronary Artery Stenosis in Dog" Transactions of ASME Journal of Biomechanical Engineering. 114. 385-390 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akihiro Kimura, et al: "Effect of Coronary Stenosis on Phasic Pattern of Septal Artery in Dog" American Journal of Physiology. 262. H1690-H1698 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Osamu Hiramatsu, et al: "Phasic Characteristics of Arterial Inflow and Venous Outflow of Right Ventricular Myocardium in Dog" American Journal of Physiology. 262. H1422-H1427 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Akihiro Kimura, et al: "Atrial Contractility affects phasic blood flow velocity of atrial small vessels in the dog" Cardiovascular Research. 26. 1219-1225 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Masami Goto, et al: "Effect of Intracoronary Nitroglycerin Administration on Phasic Pattern and Transmural Distribution of Flow during Coronary Artery Stenosis" Circulation. 85. 2296-2304 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Shinichiro Tadaoka, et al: "Effect of Left Ventricular Hypertrophy Secondary to Systematic Hypertension of Left Coronary Artery Flow Dynamics" Cardiovascular Research. 25. 955-964 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumihiko Kajiya: "Characteristic and Possible Origins of Blood Velocity Waveform of the Epicardial and Intramyocardial Coronary Circulation in Ventricular and the Atria" In Coronary Circulation in Physiological and Pathophysiological States Springer-Verlag. 1-19 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fumihiko Kajiya, et al: "A Study of Coronary Circulation by Laser Doppler Velocimetry" In Regulation of Coronary Blood Flow Springer-Verlag. 11-23 (1991)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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