• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to project page

1993 Fiscal Year Final Research Report Summary

Multilateral Research on pathogenesis, treatment and prophylaxis in acute encephalitis

Research Project

Project/Area Number 03454263
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Pediatrics
Research InstitutionNagoya University

Principal Investigator

WATANABE Kazuyoshi  Nagoya Univ.School of Medicine, Dept.Pediatrics, Professor, 医学部, 教授 (80135368)

Co-Investigator(Kenkyū-buntansha) TSUGE I.  Nagoya Univ.School of Medicine, Assistant, 医学部, 助手 (00231431)
MIMURA S.  Nagoya Univ.School of Medicine, Assistant, 医学部, 助手 (30229794)
NEGORO T.  Nagoya Univ.School of Medicine, Assistant, 医学部, 助手 (40172754)
MORISHIMA T.  Nagoya Univ.School of Medicine, Assistant Professor, 医学部, 講師 (90157892)
Project Period (FY) 1991 – 1993
KeywordsWest syndrome / Positron CT / Heerpes simplex encephalitis / PCR / Herpes simplex Virus / IUGR
Research Abstract

1) In herpes simplex encephalitis (HSE), quantitation of HSV DNA was performed and the mode of presense of viral genome was examined by PCR method. In neonatal HSE, large quantities of HSV DNA was found in CSF as a form of infectious particles, while in HSE of olfer Children, the amount of viral DNA was small and most of the viral DNA was fragmented.
2) Intrauterine growth retardation (IUGR) remains a cause of perinatal brain injury, sometime leading to neurological and intellectual impairment. We evaluated celluar composition of the brain and the liver and carbohydrate and energy metabolism in the brain tissue using sythetic thromboxane A2 (STA2) induced IUGR rats.
The results demonstrated differential organ and cellular growth failure with stimulated brain somatic in IUGR rats. Gluconeogenesis compensated for chronic fetal hypoxia and decreased glycogen store. These changes may contribute to the phenomenon called "brain sparing", but energy metabolism in IUGR brain will be liable to be disrupted for the less reserve of energy substrates.
3) Prospective studies in infants with West syndrome by means of Postron CT revealed that abnormal cortical function was found frequently in the patients. The magnitude of the abnormality has changed coresponding to the clinical course and aging, and Positron CT turbed to be normal in most of the patients.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Maeda N.,Watanabe K.,Negoro T.,Aso K.,Haga Y.,Kito M.,Ohki T.: "Transient focal cortical hypometabolism in idiopocthic West syndrome." Pediatr.Neurol. 9. 430-435 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Watanabe K.,Negoro T.,Aso K.,Matsumoto A.: "Reappraisal of intercatal electroencephalograms in in-fantile spasms." Epilepsia. 34. 679-685 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Aso K.,Watanabe K.,Negoro T.,Watanabe Y.,Umeda T.,Furune S.: "Neonatal myoclnus and neuroblastoma." Lancet. 341. 1410-1411 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Ando Y.,Kimura H.,Miwata H.,Kudo T.,Shibata M.,Morishima T.: "Quantitative Analysis of Herpes Simplex Virus DNA in Crerbrospinal Fluid of Children With Herepes Simplex Encephalitis" Journal of Medical Virology. 41. 170-173 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagae H.,Mimura S.,Kashiwamata S.,Watanabe K.,Keino H: "Acute hypoglycemia in rats after injection of tin-protoporphyrin and photoirradiation." Biomedical Research. 14. 297-299 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Keino H.,Mimura S.,Nagae H.,Banno T.,Kashiwamata S.: "Protection by L-Ascorbic Acid against Phototoxicity in Tin-Protoporphyrin-Treated Suckling Rats." Biol.Neonate.63. 183-190 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Maeda N., Watanabe K., Negoro T., Aso K., Haga Y., Kito M., Ohki T.: "Transient focal cortical hypometablism in idiopocthic West syndrome." Pediatr.Neurol.Vol 9. 430-434 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Watanabe K., Negoro T., Aso K., Matsumoto A.: "Reappraisal of interictal electroencephalograms in infantile spasms." Epilepsia. Vol 34. 679-685 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Aso K., Watanabe K., Negoro T., Horibe K., Watanabe Y., Umeda T., Furune S.: "Neonatal myoclonus and neuroblastoma." Lancet. Vol 341. 1410-1411 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Ando Y., Kimura H., Miwata H., Kudo T., Shibata M., Morishima T.: "Quantitative Analysis of Herpes Simplex Virus DNA in Cerebrospinal Fluid of Children With Herpes Simplex Encephalitis." Journal of Medical Virology. Vol 41. 170-173 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagae H., Mimura S., Kashiwamata S., Watanabe K., Keino H.: "Acute hypoglycemia in rats after injection of tin-protoporphyrin and photoirradiation." Biomedical Research. Vol 14. 297-299 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Keino H., Mimura S., Nagae H., Banno T., Kashiwamata S.: "Protection by L-Ascorbic Acid against Phototoxicity in Tin-Protoporphyrin-Treated Suckling Rats." Biol.Neonate.Vol 63. 183-190 (1993)

    • Description
      「研究成果報告書概要(欧文)」より

URL: 

Published: 1995-03-27  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi