1993 Fiscal Year Final Research Report Summary
DEVELOPMENTS IN UPPER AIRWAY MUCOSAL INFLUENZA VIRUS VACCINES
| Project/Area Number |
03454270
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| Research Category |
Grant-in-Aid for General Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Dermatology
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| Research Institution | TOKAI UNIVERSITY |
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Principal Investigator |
HAYASHI Hideki TOKAI UNIVERSITY, DEPARTMENT OF PEDIATRICS, INSTRUCTOR, 医学部, 助手 (30189659)
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| Co-Investigator(Kenkyū-buntansha) |
OHTA Kazuo DEPARTMENT OF PEDIATRICS INSTRUCTOR, 医学部, 助手 (00214122)
KUNO-SAKAI Harumi DEPARTMENT OF PEDIATRICS, ASSOCIATE PROFESSOR, 医学部, 助教授 (00102830)
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| Project Period (FY) |
1991 – 1993
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| Keywords | COMMON MUCOSAL IMMUNE SYSTEM / INACTIVATED SPLIT INFLUENZA VIRUS VACCINE / COLD ADAPTED REASSORTANT LIVE INFLUENZA VIRUS VACCINE / SYSTEMIC IMMUNE RESPONSES / MUCOSAL IMMUNE RESPONSES / INTRANASAL ADMINISTRATION OF INFLUENZA VACCINE / MUCOSAL SURFACE INFECTION / PARTIAL IMMUNITY TO INFLUENZA |
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| Research Abstract |
Concepts of common mucosal immune system has given new high lights to mucosal vaccines. Direct antigenic stimulation to mucosal surfaces by a vaccine is needed to induce mucosal immunity. Influenza is a typcal mucosal surface infection and therefore mucosal immunity plays an important role in prevention of the disease. Along this line we investigated two mucosal influenza virus vaccines both give intranasally ; concentrated inactivated split influenza virus vaccine and cold adapted reassortant live influenza virus vaccine.
Both vaccine induced systemic and mucosal immune responses. Live vaccine was effective only in nonimmune personnels, while inactivated vaccine was effective in both nonimmune and partially immune personnels.
We conclued that inactivated influenza virus vaccine given intranasally was more versatile than live influenza virus vaccine.
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