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1992 Fiscal Year Final Research Report Summary

Basic and clinical studies for the targeting therapy by using the morphometrical analysis in malignant brain tumors.

Research Project

Project/Area Number 03454342
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Tsukuba, Institution of Clinical Medicine

Principal Investigator

YOSHII Yoshihiko  Clin. Med. Neurosurg. Associat. Prof., 臨床医学系, 助教授 (50110507)

Co-Investigator(Kenkyū-buntansha) HYODO A  Clin. Med. Neurosurg. Assistant. Prof., 臨床医学系, 講師 (40167606)
ISHIKAWA Y  Clin. Med. Rad. Associat. Prof., 臨床医学系, 助教授 (10026932)
HAYAKAWA Y  Basic. Med. Rad. Assistant. Prof., 基礎医学系, 講師 (90101740)
MARUHASHI A  Basic. Med. Rad. Associat. Prof., 基礎医学系, 助教授 (30114135)
TSUJII H  Clin. Med. Rad. Prof., 臨床医学系, 教授 (50088853)
Project Period (FY) 1991 – 1992
KeywordsMalignant Brain Tumor / Targeting Therapy / Morphometry / Antitumor Effect / Lntraartenal Therapy / Proton Beam / Heterogeneity / In vivo Diagnosis
Research Abstract

Improved modern neuroimaging techniques and rigid immobilization systems alow confirmation of the target position relative to the proton beam at each treatment, treatment planning based on beam trajectory, dose at each anatomical point, bolus based on accurate assessment of density along each pixel, etc. Proton therapy in our institute showed that the patient could tolerate radiation doses 15-20% higher than those of conventional radiation therapy used. However, it was suggested that the doses needed 140-160 TDF and the tumor volume was less than 10 ml to cure the patients with malignant brain tumor. Therefore, proton beam will be a main instrument of the morphometric targeting therapy for the brain tumors. Neuroimaging is very helpful in estimating clinically the overall extent of the tumor and the peripheral margin. Gd-DTPA MRI can be used effectively in the diagnosis of tumor viability and malignancy after treatment. Furthermore, ^<201>Tl-SPECT appears to be effective for determination of the malignant viability of tumors. In the effectiveness of superselective 1 A chemotherapy of malignant tumors, the antitumor drug was transported into the tumor at an average rate of 6.3% of the total dose injected intra arterially. In calculating the ratio of the delivered ACNU dose to the tumor volume, ACNU of the average 320 mug/ml might be needed as the effective treatment. From DNA content analysis, it is suggested that the malignant brain tumors have different bilogical heterogeneity and its analysis requires further study for the morphometric targeting therapy.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] Yoshii Y: "Normal brain damage after radiotherapy of brain tumors" Clinical Oncology. 3. 278-282 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 兵頭 明夫: "悪性脳腫瘍に対する超選択的動注化学療法の有用性の検討" 日本脳神経血管内手術法研究会講演集. 5. 255-261 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshii Y: "Morphometrical analysis of GFAP positive cell in human astrocytomas" Neuro Med Chir. 32. 554-558 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshii Y: "Malignancy and viability of intraparenchymal brain tumors" Acta Neurochirurgica. 117. 187-194 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshii Y: "The robe of 201 Tl-SPET in the investigation and characterization of brain tumor in man and its response to treat meut" EJNM. 20. 39-45 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshii Y: "Proton radiation therapy for clivus chordoma" Neuro Med Chir. 33. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉井 與志彦: "Gliomaと放射線治療" にゅーろん社, 164 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 吉井 與志彦: "がん治療Q&A(幼児脳腫瘍)" 六法出版社, 121-124 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Yoshii,Y et al: "Normal brain damage after radiotherapy of brain tumors" Clinical Oncology. 3. 278-282 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hyodo,A et al: "Superselective intraarterial chemotherapy of malignant brain tumor" Proceedings of Japanese Intravascular Neurosurgery.5. 255-261 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshii,Y et al: "Morphometrical analysis of GFAP positive cell in human astrocytomas" Neuro Med Chir. 32. 554-558 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshii,Y et al: "Malignancy and viability of intraparenchymal brain tumors" Acta Neurochirurgica. 117. 187-194 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshii,Y et al: "The role of ^<201>Tl-SPET in the investigation and characterization of brain tumor in man and its response to treatment" E J N M. 20. 39-45 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshii,Y et al: "Proton radiation therapy for clivus chordoma" Neuro Med Chir. 33. (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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