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1993 Fiscal Year Final Research Report Summary

Basic and Clinical Study of Radiation Therapy for Malignant Gliomas

Research Project

Project/Area Number 03454343
Research Category

Grant-in-Aid for General Scientific Research (B)

Allocation TypeSingle-year Grants
Research Field Cerebral neurosurgery
Research InstitutionUniversity of Tokyo

Principal Investigator

MATSUTANI Masao  University of Tokyo, Department of Neurosurgery, Associate Professor, 医学部(病), 助教授 (90010454)

Co-Investigator(Kenkyū-buntansha) TAKAKURA Kintomo  Tokyo Women's Medical School, Department of Neurosurgery, Professor, 教授 (90109984)
NAGASHIMA Tadashi  University of Tokyo, Department of Neurosurgery, Assistant Professor, 医学部(病), 助手 (70217991)
MOMOSE Toshimitsu  University of Tokyo, Department of Radiology, Assistant Professor, 医学部(病), 助手 (20219992)
KAWAMOTO Shunsuke  University of Tokyo, Department of Neurosurgery, Assistant Professor, 医学部(病), 助手 (00231275)
Project Period (FY) 1991 – 1993
KeywordsMalignant Glioma / Radiation Therapy / Intraoperative Radiation Therapy
Research Abstract

In the analysis of 71 operated patients treated by conventional external radiation therapy (mean dose 60.6Gy) combined with radiosensitizing agents, the combination of ACNU and vincristine with or without nicardipine resulted in the significantly longer survival, resulting in the median survival of 101weeks.
Among various radiation modalities to deliver a high dose to the tumor area, we chose a large, single irradiation dose during the operation (intraoperative radiation therapy, IORT). Treatment results of 30 patients with glioblastoma treated by IORT (mean 18.3Gy) combined with external radiation therapy (mean 58.5Gy) resulted in a median survival of 119 weeks and a 2-year survival rate of 61% ; most recurrent tumors, however, were observed around the primary site.
The most characteristic findings obtained in irradiated glioblastoma tissue were extensive ischemic coagulation necrosis and coexisting radioresistant grade I and II viable tumor areas. The labeling index of bromodeoxyuridine (BUdR), which is taken up by cells in S-phase, was analyzed after radiation therapy. The mean LI fell to 3.8% from the initial 8.2%, and the lowest LI,less than 0.1%, was obtained in cases treated with a 70Gy dose.
These results apparently indicate that areas adjacent to the margin of almost complete removal should be irradiated with a sufficient dose to sterilize the remaining malignant remnants and that infiltrating areas around the tumor bulk should be treated by the conventional radiation therapy with a dose of 70Gy or more.

  • Research Products

    (22 results)

All Other

All Publications (22 results)

  • [Publications] 松谷 雅生: "悪性Gliomaの局所再発と治療" Karkinos. 4. 1189-1195 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松谷 雅生、他: "悪性脳腫瘍の手術と放射線治療の進歩-膠芽腫(glioblastoma)と転移性脳腫瘍について" 癌と化学療法. 18. 174-179 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsutani M,et al.: "Intraoperative radiation therapy for malignant brain tumours:Rationale,method,and treatment results of cerebral glioblastomas." Acta Neurochir (wien). (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Fujimaki T, Matsutani M,et al.: "Correlation between bromodexyuridine-labeling indices and patient prognosis in cerebral astrocytic tumors of adults." Cancer. 67. 1629-1634 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小須田 茂、松谷 雅生、他: "201 TICI SPECT による脳腫瘍再発と放射線脳壊死の鑑別診断" 日本医放会誌. 51. 415-421 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松谷 雅生: "ガンマーナイフ:悪性脳腫瘍への応用" 外科. 55. 1567-1569 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nagane M, Matsutani M,et al: "Expression of O -methylguatine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors." Jpn J Clin Oncol. 22. 143-149 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Nakagawa K, Matsutani M,et al.: "Radiation therapy of well-differentiated neuroblastoma and central neurocytoma." Cancer. 72. 1350-1355 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsutani M,et al.: "Radiation therapy combined with radiosensitizing agents for cerebral glioblastoma in adults." J Neuro-Oncol. (in press). (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 浅井 昭雄、松谷 雅生、他: "放射線治療に伴う正常脳組織障害" 脳神経ジャーナル. 1. 116-122 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 松谷 雅生、他: "高齢者glioblastomaの治療成績" Geriatric Neurosurg. 5. 56-60 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Matsutani M: "Treatment of recurrect malignant gliomas. (in Japanese)" Karkinos. 4. 1189-1195 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsutani M,et al.: "Advance of surgery and radiation therapy for glioblastoma and metastatic tumors. (in Japanese)" Jpn J Chemothr. 18. 174-179 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujimaki T,Matsutani M,et al.: "Correlation between bromodeoxyuridine-labeling indices and patient prognosis in cerebral astrocytic tumors of adults" Cancer. 67. 1629-1634 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kosuda S,Matsutani M,et al.: "Differential diagnosis between recurrence of brain tumor and radiation necrosis by ^<201>TI SPECT.(in Japanese)" Nippon Acta Radiol. 51. 415-421 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Asai A,Matsutani M,et al.: "Radiation-induced damages to the brain. (in Japanese)" Jpn J Neurosurg. 1. 116-122 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nagane M,Matsutani M,et al.: "Expression of O^6-methylguatine-DNA methyltransferase and chloroethylnitrosourea resistance of human brain tumors" Jpn J Clin Oncol. 22. 143-149 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsutani M,et al.: "Treatment results of aged patients with glioblastoma. (in Japanese)" Geriatric Neurosurg. 5. 56-60 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsutani M: "Gamma-knife for malignant brain tumors. (in Japanese)" Surgery. 55. 1567-1569 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Nakagawa K,Matsutani M,et al.: "Radiation therapy of well-differentiated neuroblastoma and central neurocytoma" Cancer. 72. 1350-1355 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matsutani M,et al.: "Radiation therapy combined with radiosensitizing agents for cerebral glioblastoma in adults" J Neuro-Oncol. (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Matautani M,et al.: "Intraoperative radiation therapy for malignant brain tumors : Rationale, method, and treatment results of cerebral glioblastoma" Acta Neurochir (Wien). (in press). (1994)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1996-04-15  

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