1993 Fiscal Year Final Research Report Summary
Development of the Resins having Antibacterial Activity
| Project/Area Number |
03555196
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
高分子合成
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| Research Institution | Kumamoto university |
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Principal Investigator |
NONAKA Takamasa Kumamoto University, Applied chemistry, Professor, 工学部, 教授 (50040423)
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| Co-Investigator(Kenkyū-buntansha) |
TAMURA Shuji Tokyo Yuki Kagaku Co., Chief of Staff, 東京研究所, 主席部員
UEMURA Yasuko Kumamoto University, Applied chemistry, Assistant Professor, 工学部, 助手 (70203487)
KURIHARA Seiji Kumamoto University, Applied chemistry, Lecturer, 工学部, 講師 (50225265)
KIDA Kenji Kumamoto University, Applied chemistry, Associate Professor, 工学部, 助教授 (00195306)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Insoluble disinfectant / Quaternary ammonium group / Phosphonium groups / Antibacterial activity / Escherichia Coli / Staphylococcus aureus / Copolymer Beads / Adsorption |
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| Research Abstract |
Copolymer beads having chlorohysroxyl group (RCG) were prepared by treating macroreticular glycidyl methacrylate-divinylbenzene copolymer beads with hydrogen chloride. Copolymer beads bearing quaternary ammonium groups or phosphonium groups were prepared by treating RCG or stirene tetraethyleneglycol dimethacrylate(RCS4G) with amines or phosphines. Triethyl amine, N, N-dimethyl-n octhylamine N, N-dimethyl-n-dodecylamine(DMDA), N, N-dimethy-n-hexadecylamine were used as amine. Triethyl phosphine (TEP), Tributyl phosphine (TBP), and Trioctyl phosphine (TOP), and so on were used as phosphine. The adsorption of sodium benzenesulfonate(SBS), sodium n-dodecylbenzenesulfonate (SDBS), and bacteria with the resins containing quaternary ammonium groups(RCG-Q or RCS4G-Q) was investigated under various conditions. And their antibacterial activity was examined against Escherichia col (E.coli) and Staphylococcus aureus (S.aureus).
RCG-Q and RCS4G-Q had antibacterial activity against E.coli and S.aureus.SBS and SDBS could be adsorbed with RCG-Q from the solution over wide pH(4.5-8.5) range and with ionic strength (0-0.3). RCG-TOP(OH type) exhibited antibacterial activity against E.coli in water, but RCG-TEP and RCG-TBP had no activity. Scanning electron micrograph showed that bacteria were adsorbed on those resins. Both antibacterial activity and adsorption ability of the resins were not only affected by the structures of quaternary ammonium groups or phosphonium groups but also the kinds of matrix of copolymer bead into which those functional groups introduced.
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