1992 Fiscal Year Final Research Report Summary
Development of antihypertensive drugs: L-arginine and its derivatives as a precursor of endothelium-derived relaxing factor
| Project/Area Number |
03557012
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
General pharmacology
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| Research Institution | KEIO UNIVERSITY |
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Principal Investigator |
NAKAKI Toshio KEIO UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF PHARMACOLOGY, ASSISTANT PROFESSOR, 医学部, 講師 (30164148)
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| Co-Investigator(Kenkyū-buntansha) |
SONAKA Ichiro AJINOMOTO CO., INC., CENTRAL RESEARCH LABORATORIES, RESEARCHER, 中央研究所, 研究員
SUZUKI Hiromichi KEIO UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, ASSOCIATE P, 医学部, 助教授 (80129494)
SARUTA Takao KEIO UNIVERSITY SCHOOL OF MEDICINE, DEPARTMENT OF INTERNAL MEDICINE, PROFESSOR, 医学部, 教授 (70051571)
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| Project Period (FY) |
1991 – 1992
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| Keywords | L-arginine / Antihypertensive drug / Nitric oxide / EDRF / Plasma cGMP / Nitrite / nitrate / Citrulline / Endothelium |
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| Research Abstract |
Intravenous administration of L-arginine to normotensive healthy volunteers caused a slight reduction of systemic blood pressure. To essential and secondary hypertension it caused a marked decrease in systemic blood pressure. Based on observations of the increase in plasma cyclic GMP and citrulline, as well as urinary nitrite/nitrate and increased output of nitric oxide from cultured endothelial cells, the antihypertensive effect of L-arginine was probably due to an increase in nitric oxide synthesis/release in vivo. L-arginine suppressed plasma aldosterone. These results suggest that exogenous L-arginine produces a vasodilatory effect by increasing NO production and that L-arginine or released NO modulates the release of neuroendocrine hormones in hypertensive subjects.
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