1993 Fiscal Year Final Research Report Summary
Scintigraphic assessment of bowel absorption based on PET
| Project/Area Number |
03557055
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | Tohoku University |
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Principal Investigator |
CHIBA Toshio Tohoku University School of Medicine, Department of Pediatric Surgery, Assistant Professor, 医学部・附属病院・小児外科, 教授 (20171944)
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| Co-Investigator(Kenkyū-buntansha) |
ITOH Masatoshi Tohoku University Cyclotron Radio-isotope Center, Assistant Professor, サイクロトロンラジオアイソトープセンター, 助教授 (00125501)
HAYASHI Yutaka Tohoku University School of Medicine, Department of Pediatric Surgery, Assistant, 医学部・小児外科, 助教授 (40125638)
OHI Ryoji Tohoku University School of Medicine, Department of Pediatric Surgery, Professor, 医学部・小児外科, 教授 (50004734)
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| Project Period (FY) |
1991 – 1993
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| Keywords | bowel absorption / PET / ^<11>C-methionine / ^<18>F-FD-galactose / 糖質吸収能 / ^<18>F-FD-ガラクトース / 脂質吸収能 / ^<123>I-BMIPP |
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| Research Abstract |
Purpose of our study is to establish semi-quantitative a convenient test for measuring dynamic bowel absorption. Positron Emission Tomography (PET) was quite helpful in assessing absorption of intraluminal nutritious staff, because serially taken hepatic images on PET can define visually the amount of radioactive nutrients absorbed via portal venous system. Results of our investigations are outlined as below. First, initial absorption of amino acid (^<11>C-methionine) which is soon bollowed by plateau phase is quite efficient as represented by time activity curve (TAC). Most important is that TAC could be controlled by reducing specific radioactivity of amino acid because original tests using highly radioactive substrate feiled to differentiate normal volunteer from patients with short bowels. Next, carbohydrate (^<18>F-FD-galactose) was used based on the out comes of amino acid study. Likewise, galactose absorption was clearly demonstrated on PET images. Its TAC was non-phasic showed a slow gradual rise, which was distinctly different from that of amino acid.
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