1993 Fiscal Year Final Research Report Summary
Synthetic Study on Homoisocarbacyclin
| Project/Area Number |
03557092
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| Research Category |
Grant-in-Aid for Developmental Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Research Field |
Chemical pharmacy
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| Research Institution | University of Tokyo (1992-1993)
Hokkaido University (1991) |
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Principal Investigator |
SHIBASAKI Masakatsu University of Tokyo, Faculty of Pharmaceutical Sciences, Professor, 薬学部, 教授 (30112767)
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| Co-Investigator(Kenkyū-buntansha) |
KOGI Kenntaro Toaeiyo Senior Research, 福島研究所, 主任研究員
SODEOKA Mikiko University of Tokyo, Faculty of Pharmaceutical Sciences, Research Associate, 薬学部, 助手 (60192142)
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| Project Period (FY) |
1991 – 1993
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| Keywords | Carbacyclin / Isocarbacyclin / Chemically Stable Prostacyclin Analog / Inhibitor of platelet aggregation |
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| Research Abstract |
In order to develop a new drug many homoisocarbacyclin analogs have beensynthesized. Anong those1-9, the homoisocarbacyclin amalog 7 has been selected as a candidate for further investigation.
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[Publications] S.Narita, A.Takahashi, T.Aoki, H.Sato, S.Satoh, S.Yamada, M.Kudo, T.Yamaguchi, K.Kogi, and M.Shibasaki: "Syntheses and Biological Activities of Chemically Stable Prostacyclin Mimics with cis-Bicyclo [ 4,3,0 ]nonene Ring System : The Novel Homoisocarbacyclin Analogues" Bioorganic & Med.Chemistry. 1. 77-118 (1993)
Description
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