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1992 Fiscal Year Final Research Report Summary

Morphological analysis on paracrine action of brain-gut hormones.

Research Project

Project/Area Number 03670006
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General anatomy (including Histology/Embryology)
Research InstitutionNiigata University

Principal Investigator

IWANAGA Toshihiko  Niigata Univ. School of Medicine, Assist. Prof., 医学部, 助教授 (10160128)

Project Period (FY) 1991 – 1992
KeywordsBrain-gut peptides / Local hormones / Paracrine secretion / GRP / CGRP / Serotonin / VIP / Diarrhea
Research Abstract

1.In order to analyze local hormone-like (paracrine) actions of brain-gut hormones, characteristic distribution of peptidergic neurons was investigated in the stomach, urethra and trachea. The mucosa of the gastric corpus was innervated predominantly by GRP-containing cholinergic neurons. Observation of whole mount preparations of the urethral mucosa revealed entire distribution of CGRP neurons and serotonin endocrine cells and their relationship. The tracheal epithelium was extremely rich in CGRP nerve fibers.
2.Physiological study on local hormone-like actions Serotonin and VIP play an important role in diarrhea. Morphological and physiological studies in dogs demonstrated that serotonin secreted from epithelial EC cells stimulated the release of VIP from adjacent VIP-containing neurons in the lamina propria to cause severe diarrhea.
3.Local administration of brain-gut peptides by means of osmotic pump. Osmotic micropump was more available than pellets to locally administer the peptides. GRP and CGRP or substance P were continuously and regularly injected to the mucosa of gastric corpus and trachea, respectively. It was shown that the peptides caused infiltration of white blood cells and mast cells at the sites where the peptides were injected. Detailed analysis under microscopes is in progress.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] IWANAGA,Toshihiko: "GRP-containing nerves in the rat stomach and stress-induced depletion of their synaptic vesicles.An electron microscope study." Arch.Histol.Cytol.54. 573-580 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩永 敏彦: "胃体部粘膜における神経網の分布と微細構造" 消化管ホルモン. 10. 472-476 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 岩永 敏彦: "潰瘍発生のメカニズム神経と血管の分布から考える" 消化性潰瘍. 10. 140-151 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] TAMAKI,Makoto: "CGRP-immunoreactive nerve terminals in the whole mount preparations of the dog urethra." Arch.Histol.Cytol.55. 1-11 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] TERADA,Masaki: "CGRP-immunoreactive nervs in the tracheal epithelium of rats:an immunohistochemical study by means of whole mount preparations." Arch.Histol.Cytol.55. 219-233 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] IWANAGA,Toshihiko: "Enterochromaffin(EC) cells in the gut with special reference to their role in diarrhea." Biomed.Res.(1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwanaga Toshihiko: "GRP-containing nerves in the rat stomach and stress-induced depletion of their synaptic vesicles. An electron microscope study." Arch. Histol. Cytol.54. 573-580 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwanaga Toshihiko: "Distribution and ultrastructure of nerve fibers in the mucosa of the gastric body." Gut Hormones. 10. 472-476 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwanaga Toshihiko: "Mechanism of ulceration with special reference to distribution of neurons and blood vessels." Peptic Ulcer. 10. 140-151 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tamaki Makoto: "CGRP-immunoreactive nerve terminals in the whole mount preparations of the dog urethra." Arch. Histol. Cytol.55. 1-11 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Terada Masaki: "CGRP-immunoreactive nerve in the tracheal epithelium of rats: an immunohistochemical study by means of whole mount preparations." Arch. Histol. Cytol.55. 219-233 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwanaga Toshihiko: "Enterochromaffin (EC) cells in the gut with special reference to their role in diarrhea." Biomed. Res.(1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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