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1992 Fiscal Year Final Research Report Summary

Neuronal mechanism generating vertical eye position signals.

Research Project

Project/Area Number 03670050
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Neurophysiology and muscle physiology
Research InstitutionUniversity of Tsukuba

Principal Investigator

YOSHIDA Kaoru  Univ. Tsukuba, Inst of Basic Med. Sci. Associate Professor, 基礎医学系, 助教授 (50111373)

Project Period (FY) 1991 – 1992
Keywordsvertical eye movement / eye position / vestibular nucleus / interstitial nucleus of Cajal
Research Abstract

The vestibular nucleus (VN) and the interstitial nucleus of Cajal (INC) contain neurons with activity related to vertical eye movement. To examine a possible interaction between the two nuclei, projection of INC neurons to VN and vestibular input to these neurons were studied in the alert cat.
Sixty-two INC neurons with activity related to vertical eye position were tested for the response to stimulation of the ipsilateral VN. Forty-one had a downward and 21 an upward on-direction (to be called downward and upward neurons, respectively). Thirteen of 41 downward neurons were antidromically activated following stimulation of the ipsilateral VN with thresholds 36 to 220 muA. None of 21 upward neurons showed antidromic responses. Histological study showed that the stimulation sites had been in the ventral part of VN at the level of the Vlth nucleus. All the downward INC neurons antidromically activated from VN responded orthodromically to stimulation of the contralateral vestibular nerve at disynaptic latencies (1.3 to 2.0 msec). We suggest that secondary VN neurons carrying vertical eye position signals make excitatory connections with contralateral downward INC neurons which in turn send the signal ipsilaterally to VN. This neural pathway may form an important part of the neural circuitry responsible for the generation of vertical eye position signals.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] IWAMOTO,Y.,KITAMA,T.and YOSHIDA,K.: "Role of premotor vestibular neurons in verticalgaza." Acta Otolaryngol.Supple.481. 187-190 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] IWAMOTO,Y.,KITAMA,T.and YOSIDA,K.: "Eye movement-related activity in the vestibulo-ocular and vestibulocollic in the cat." The Head-Neck Sensory-Motor System.Eds.A.Berthoz,W.Graf and P.P.Vidai,Oxford. 273-278 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] KITAMA,T.,SHIMAZU,H.,TANAKA,M.andYOSHIDA,K.: "Vestibular and visual interaction in generation of rapid eye movements" Ann.New York Acad.Sci.656. 396-407 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] IWAMOTO,Y.,CHIMOTO,S.and YOSHIDA,K.: "Verticaleye movement-related neurons in the interstitial nucleus of Cajal project to the vestibular nucleus." Soc.Neurosci.Abster.18. 27 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] CHIMOTO,S.,IWAMOTO,Y.and YOSHIDA,K.: "Functional connections between interstitial nucleus of Cajal and vestibular nucleus:Relation to vertical eye movements." Neurosci.Res.,Supple.17. S217 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] CHIMOTO,S.,IWAMOTO,Y.and YOSHIDA,K.: "Projections of vertical eye movement-related neurons in the interstitial nucleus of Cajal to the vestibular nucleus in the cat." Neurosci.Res.15. 293-298 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iwamoto, Y., Kitama, T. and Yoshida, K.: "Role of premotor vestibular nucleus neurons in vertical gaze." Acta Otolaryngol.481. 187-190 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwamoto, Y., Kitama, T. and Yoshida, K.: "Eye movement-related activity in the vestibulo-ocular and vestibulocollic pathways in the cat." The Head-Neck Sensory-Motor System. Eds. A. Berthoz, W. Graf and P.P. Vidal, Acta Otolaryngol. Oxford University Press, New York-Oxford. 273-278 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kitama, T., Shimazu, H., Tanaka, M. and Yoshida, K.: "Vestibular and visual interaction in generation of rapid eye movements." Ann. New York Acad. Sci.656. 396-407 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iwamoto, Y., Chimoto, S. and Yoshida, K.: "Vertical eye movement-related neurons in the interstitial nucleus of Cajal project to the vestibular nucleus." Soc. Neurosci. Abstr.18. 27 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chimoto, S., Iwamoto, Y. and Yoshida, K.: "Functional connections between interstitial nucleus of Cajal and vestibular nucleus: Relation to vertical eye movements." Neurosci. Res., Supple.17. S217 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chimoto, S., Iwamoto, Y. and Yoshida, K.: "Projections of vertical eye movement-related neurons in the interstitial nucleus of Cajal to the vestibular nucleus in the cat." Neurosci. Res.15. 293-298 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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