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1992 Fiscal Year Final Research Report Summary

Effects of nutrition on the development of autoimmune disease and allergy

Research Project

Project/Area Number 03670080
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 環境生理学(含体力医学・栄養生理学)
Research InstitutionKYUSYU UNIVERSITY

Principal Investigator

KUBO Chiharu  Kyusyu University, Faculty of Medicine, Professor, 医学部, 教授 (80117100)

Project Period (FY) 1991 – 1992
KeywordsNutrition / Immune function / Autoimmune disease / Autoantibody / Calorie restriction / Life span / Allergy / Bronchial asthma
Research Abstract

1.Effects of nutrition on development of autoimmune disease and immune functions in autoimmune-prome mice.
(1) Total calorie intake is the most crucial factor for maintaining immune functions and preventing the development of disease of aging. Restriction of calorie intake without malnutrition delayed development of glomerulonephritic and prolonged life-span of (NZB x NZW) F1 mice.
(2)With higher calorie intake the energy source did not significantly affect logevity. However, high fat diet did not give the same protection as did carbohydrate diet under the restriction of energy intake.
(3)These dietary influence was also observed when dietary restriction was imposed after onset of autoimmune disease.
(4)The amount of food intake depends on the strain of mice. Calorie restriction was most effective near 60% intake of ad libitum feeding.
2.Effect of nutrition on immune functions in normal mice. Responses to phytohemagglutinin and mixed lymphocyte reaction of spleen cells from C57BL/6 mice were well maintained in restriction of energy intake group. Total calorie intake is most important factor. This phenomenon is same as autoimmune-prome mice.
3.Effect of nutrition on konjac bronchial asthma in guinea pig.
(1)Degree of attack by antigen challenge was higher in fat diet group. Especially, death rate was highest in guinea pigs with restricted energy intake of a fat diet.
(2)Recovery of attack was later in group of ad libitum-fed carbohydrate diet compared to that of restricted energy intake of carbohydrate diet.
(3)The degree of immediate skin reaction was not significantly different in four groups. However, delayed skin reaction was strong in high calorie group. Therefore, restricted energy intake of high carbohydrate diet is most desirable for prevention of allergy.

  • Research Products

    (11 results)

All Other

All Publications (11 results)

  • [Publications] Chiharu Kubo(4名): "Effects of calorie restriction on immunological functions and development of autoimmune disease in NZB mice." Proceedings of the society for experimental biology and medicine. 201. 192-199 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Atsunori Ishida(6名): "Consumption of milk from cows immunized with intestinal bacteriainfluences age-related changes in immune competence in mice" Journal of Nutrition.122. 1875-1883 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Chiharu Kubo(4名): "The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mice." Proc.Natl.Acad.Sci.USA.89. 3145-3149 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Hiroshi Nakano(5名): "Effect of REM-sleep deprivation on immune function in rats." Med.Sci.Res.20. 65-66 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久保 千春(1名): "栄養と免疫・アレルギー" 皮膚. 34. 1-9 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 久保 千春(5名): "絶食・断眠ストレスと免疫." 心身医学. 32. 59-65 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Shinji Murosaki Yasunobu Yoshikai Chiharu Kubo Atsunori Ishida Tomonobu Sato Katsumi Endo Kikuo Nomoto: "Influence of intake of immune milk on onset of renal disease in (NZB X NZW)F, mice fed ad libitum or restricted energy intake." J. Nutri. 121(2). 1860-1868 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Hiroshi Nakano Chiharu Kubo Hiroshi Sogawa Hideki Teshima Tetsuya Nakagawa: "Effect of REM-sleep deprivation on immune function in rats." Medical science Research. 20. 65-66 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chiharu Kubo Amar Gajjar B.Connor Johnson Robert A Good: "The effects of dietary restriction on immune function and development of autoimmune disease in BXSB mice." Proc. Natl. Acad. Sci. USA.89. 3145-3149 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Atsunori Ishida Yasunobu Yoshikai Shingi Murosaki Chiharu Kubo Yoshio Hidaka Kikuo Nomoto: "Protective effect of oral administration of immune milk derived from cows immunized with intestinal bacteria on age-related decline of immunological functions in mice." J. Nutri.122. 1875-1883 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Chiharu Kubo B.Connor Johnson Noorbibi K. Day Robert A. Good: "Effects of calorie restriction on immunological functions and development of autoimmune disease in NZB mice." Proc. Soc. Exp. Biol. Med.201. 192-199 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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