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1992 Fiscal Year Final Research Report Summary

Long term potentiation of paintransmission at the spinal level

Research Project

Project/Area Number 03670096
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field General pharmacology
Research InstitutionTokyo Medical and Dental University

Principal Investigator

YOSHIOKA Koichi  Faculty of Medicine, Tokyo Medical and Dental University, Associate Professor, 医学部, 助教授 (00143579)

Project Period (FY) 1991 – 1992
Keywordssubstance P / tachykinins / spinal cord / pain / serotonin
Research Abstract

1. Transmitter mechanisms of a long-lasting inhibition of the monosynaptic reflex (MSR)induced by stimulation of the descending pathway was investigated in the isolated spinal cord of the neonatal rat. The descending inhibition was markedly potentiated by a 5-hydroxytryptamine (5-HT) uptake blocker and was blocked by a 5-HT antagonist, suggesting the involvement of 5-HT in this inhibition.
2. The mechanisms of a cutaneous nerve-evoked inhibition of MSR were studied in the spinal cord-peripheral nerve preparation. Conditioning stimulation of the saphenous nerve evoked an inhibition of the MSR. This inhibition was potentiated by an anticholinesterase and almost completely blocked by atropine. From the effects of muscarinic agonists and antagonists, it was suggested that the receptors involved in the inhibition of MSR are of M2 type.
3. A possible mechanism of inactivation of tachykinins released from nerve terminals is enzymatic degradation. To investigate this possibility, effect of peptidase inhibitors on C-fiber evoked responses was examined using an isolated spinal cord-saphenous nerve preparation of the newborn rat. A slow depolarization of the L3 ventral root evoked by the saphenous nerve stimulation was enhanced by application of a mixture of peptidase inhibitors in the presence of naloxone. This result suggests that enzymatic degradation plays a physiological role in termination of neurotransmitter action of tachykinins.

  • Research Products

    (9 results)

All Other

All Publications (9 results)

  • [Publications] YOMONO H.S.et al.: "Serotonergic fibers induce a long-lasting inhibition of monosynaptic reflex in the neonatal rat spinal cord." Neuroscience. 47. 521-531 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] YANAGISAWA M.et al.: "Enzymatic inactivation of tachykinin neurotransmitters in the isolated spinal cord of the newborn rat." Neurosci.Res.15. 289-292 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SUZUKI H.et al.: "Potentiating effect of peptidase inhibitors on a C fiber-evoked response in the isolated spinal cord preparation of the neonatal rat." Regul.Pept.Suppl.1. S152 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MAEHARA T.et al.: "Substance P-eboked release of aminoacid transmitters from the newborn rat spinal cord." Regul.Pept.Suppl.1. S102 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] SUZUKI H.et al.: "Peptidase inhibitors potentiate a cutaneous nerve-evoked slow depolarization in the isolated spinal cord of the neonatal rat." Neurosci.Res.Suppl.17. S118 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] MAEHARA.T.et al.: "Effect of sodium and chloride ions on substance P-induced release of GABA from the neonatal rat spinal cord." Neurosci.Res.Suppl.17. S117 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Sakuma M.: "Substance P-evoked release of GABA from isolated spinal cord of the newborn rat." Neuroscience. 45. 323-330 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Kobayashi N.: "Substance P-evoked release of acetylcholine from isolated spinal cord of the newborn rat." Neuroscience. 45. 330-337 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Yoshioka K.: "Cutaneous nerve-evoked cholinergic inhibition of monosynaptic reflex in the neonatal rat spinal cord." Neuroscience. 38. 195-203 (1990)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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