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1992 Fiscal Year Final Research Report Summary

Tyrosine phosphrylating protein critical for cell-cell adhesion

Research Project

Project/Area Number 03670139
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Pathological medical chemistry
Research InstitutionNagoya University

Principal Investigator

HAMAGUCHI Michinari  Nagoya Univ. School of Med. Asso. Prof., 医学部, 助教授 (90135351)

Project Period (FY) 1991 – 1992
Keywordssrc / tyrosine phosphorylation / cadherin / catenin / cytoskeleton
Research Abstract

Transformation of chick embryonic fibroblasts with Rous sarcoma virus strongly suppresses N-cadherin-mediated cell-cell adhesion, without inhibiting its expression. This suppression is correlated with tyrosine phosphorylation of N-cadherin and catenins, the cadherin-associated proteins, which are know to regulate cadherin function. Experiments with non-myristylation and temperature-sensitive mutants of RSV and with herbimycin A, a potent inhibitor of tyrosine kinases, suggest that both the suppression of cell adhesion and tyrosine phosphorylation of catenins are highly transformation-specific.

  • Research Products

    (6 results)

All Other

All Publications (6 results)

  • [Publications] M.Hamaguchi: "p60v-src causes tyrosine phosphorylation and inactivation of the N-cadherin-catenin cell adhesion system" EMBO J.12. 307-314 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Hamaguchi: "Herbimycin A inhibits the association of p60v-src with cytoskeletal structure and with phosphatidylinositol3′kinase" Oncogene. 8. 559-564 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] N.Matsuyoshi: "Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts" J.Cell Biol.118. 703-714 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] M.Hamaguchi: "p60v-src causes tyrosine phosphorylation of the N-cadherin-catenin cell adhesion system." EMBO J.12. 307-314 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] M.Hamaguchi: "Herbimycin A inhibits the association of p60v-src with cytoskeletal structure and with phosphatidylinositol 3'kinase." Oncogene. 8. 559-564 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] N.Matsuyoshi: "Cadherin-mediated cell-cell adhesion is perturbed by v-src tyrosine phosphorylation in metastatic fibroblasts." J. Cell Biol.118. 703-714 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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