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1993 Fiscal Year Final Research Report Summary

Phenotype and Genotype of Thymoma and Yhymic Carcimona

Research Project

Project/Area Number 03670160
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Human pathology
Research InstitutionNagoya City University

Principal Investigator

EIMOTO Tadaaki  Nagoya City University School of Medicine Professor, 医学部, 教授 (60140779)

Co-Investigator(Kenkyū-buntansha) TATEYAMA Hisashi  Nagoya City University School of Medicine Assistant, 医学部, 助手 (80207068)
Project Period (FY) 1991 – 1993
KeywordsThymus / Thymoma / Thymic carcinoma / Immunohistochemistry / Cytokeratin / Cellulat prokiferative activity / Tumor suppressor gene / p53 sequencing
Research Abstract

1. Cytokeratin (CK) patern in thymomas was compared with that in normal thymic epithelium by immunohistochemistry on the frozen sections. It was possible to classify the tumors into cortical (CK8+, 19+), medullary (CK13+, 14+, 19+), corpuscular (CK14-), and mixed types, although subcapsular type (CK7+, 14+, 19+) was not recognized.
2. Thymic carcinomas were histologically and immunohistochemically subclassified into squamous cell, adenosquamous, lymphoepithelioma-like, clear cell, mucoepidermoid, basalaid, cell carcinoma and atypical carcinoid. All the subtypes showed features compatibel with mesodermal derivation, with differntiation toward pharyngeal or medullary duct of neuroendocrine epithelia.
3. Tumor cell proliferation was studied by quantification of argrophilic nucleolar organizer regions and proliferating cell nclear antigen. The labeling indeces of these markers were not defferent between noninvasive and invasive/metastatic thymomas, but were significantky differnt between thymomas and thymic carcinomas. The results suggested that thymoma is essentially a low-grade malignant tumor regardless of the stages and that the designation of "malignant" thymoma is inadequate because of redundancy and confusion with thymic carcinoma.
4. Abnormal p53 protein and mutated p53 protein was immunohistochemically demonstrated in almost all the thymomas, but more in the abvanced stage tumors. Thymic carcinomas showed a prominent expression of the abnormal protein. Sequencing of the p53 gene revealed point mutations in low expressors of the protein as well as in high expressors, although the location of the mutation was not constant. It was concluded that abnormality in p53 gene is an early event in thymic epithelial tumors.

  • Research Products

    (14 results)

All Other

All Publications (14 results)

  • [Publications] 立山尚,稲垣宏,藤吉行雄,水野力,多田豊曠,栄本忠昭: "胸腺癌の免疫組織化学的検討" 日本病理学会会誌. 81. 159 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 藤吉行雄,立山尚,稲垣宏,多田豊曠,栄本忠昭,水野力: "胸腺腫におけるサイトケラチン発現パターンの免疫組織化学的検討" 日本病理学会会誌. 81. 201 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tateyama H,Mizuno T,Tada T,Eimoto T,Hashimoto T,Masaoka A: "Thymic epithelial tumours.Evaluation of malignant grade by quantification of proliferating cell nuclear antigen and nucleolar organizer regions." Virchows Arch(Pathol Anat). 422. 265-269 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 栄本忠昭: "重症筋無力症における胸腺" 病理と臨床. 11. 24-28 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 立山尚,多田豊曠,栄本忠昭: "胸腺癌の組織型" 病理と臨床. 11. 47-52 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 立山尚,水野力,稲垣宏,藤吉行雄,多田豊曠,栄本忠昭: "胸腺上皮性腫瘍における異常p53蛋白発現" 日本病理学会会誌. 83. 239 (1994)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 栄本忠昭(分担執筆): "上皮性胸腺腫瘍の基礎と臨床(正岡昭,松山睦司編)" 癌と化学療法社, 20 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Tateyama H, Inagaki H, Fujiyoshi Y, Mizuno T, Tada T, Eimoto T: "Immunohistochemical examination of thymic carcinomas." Trans Soc Pathol Jpn. 81. 159 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Fujiyoshi Y, Tateyama H, Inagaki H, Tada T, Eimoto T, Mizuno T: "Patterns of cytokeratin expression if thymamas. An immunohistochemical study." Trans Soc Pathol Jpn. 91. 201 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tateyama H, Mizuno T, Tada T, Eimoto T, Hashimoto T,Masaoka A: "Thymic epithelial tumours. Evaluation of malignant grake by quantification of proliferating cell muclear antigen and mucleolar organizer regions." Virchows Arch A. 422. 265-269 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eimoto T: "Thymus in myasthenia gravis" Pathol Clin Med. 11. 24-28 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tateyama H, Tada T, Eimoto T: "Histologic types of thymic carcinoma" Pathol Clin Med. 11. 47-52 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Tateyama H, Mizuno T, Inagaki H, Fujiyoshi Y, Tada T, Eimoto T: "Abnormal p53 protein expression in thymic epithelial tumors." Trans Soc Pathol Jpn. 83. 239 (1994)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Eimoto T: Spectrum of thymic carciomas. Basics and Clinics of Thymic Epithelial Tumors, ed. by Masaoka A, Matsuyama M, Gan-to-Kagakuryoho-Sya, 91-90 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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