1992 Fiscal Year Final Research Report Summary
Establishment of a New Kind of Experimental Animal to Detect Delayed Neurotoxicity Caused by Organophosphorus Pesticides.
| Project/Area Number |
03670269
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Hygiene
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| Research Institution | Kochi Medical School |
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Principal Investigator |
KINEBUCHI Hideo Kochi Medical School, Department of Environmental and Occupational Health, Professor, 医学部, 教授 (90045641)
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| Co-Investigator(Kenkyū-buntansha) |
SHIRAISHI Noriyuki Kochi Medical School, Department of Environmental and Occupational Health, Assis, 医学部, 助手 (30133169)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Organophosphate / Delayed Neurotoxicity / Quail |
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| Research Abstract |
Organophosphates inhibit the activity of cholinesterase and cause acute poisoning. This effect is applicable to pesticides. A few organophosphates, however, produce characteristic delayed neuropathy in exposed animals. Ataxia of legs is seen between one and three weeks after recovery from acute poisoning. The symptomes often develop into fatal paralysis. Some organophosphorus pesticides were recognized to be compounds of this kind. Hens have been used as the most sensitive animal in delayed neurotoxicity studies with organophosphates. However, it is not easy to deal with many hens at the same time, with respect to breeding space or labor in the experiment. We thought it would be more convenient if we could use smaller sensitive animal. We tried Japanese quails instead of hens and established them as a new kind of experimental animal.
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