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1992 Fiscal Year Final Research Report Summary

Morphological and cytogenetic effects of magnetic fields on mouse post blastocyst development in vitro

Research Project

Project/Area Number 03670282
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 公衆衛生学
Research InstitutionYamanashi Medical University

Principal Investigator

IIJIMA Sumio  Yamanashi Medical University, Department of Health Science,Associate Professor, 医学部, 助教授 (70114361)

Project Period (FY) 1991 – 1992
Keywordsmagnetic fields / ethylmethanesulfonate(EMS) / NiCl_2 / blastocyst / inner cell mass / SCE
Research Abstract

Randomly bred Balb/c mice were used. Late blastocysts collected on Day 4 of pregnancy (plug day:Day 1) were exposed for six days to chemicals ( EMS and NiCl_2) with r without magnetic fields (MF;0.8T for 30 mintiutes before culture). Morphological embryonic development were examined as the parameters of embryotoxicity. When blastocysts were reted with chemicals, the number of embryos with growing inner cell mass (ICMs) and ICMs that were differentiated into primary endoderm and ectoderm were significantly reduced dose-dependently.The number of embryos forming trophoblast outgrowths was significantly reduced dose-dependently,too. However,there were no significant differences between MF-exposed and MF-unexposed groups in all endpoints. Of the morphological developmental endpoints in vitro, the formation of two-layer ICMs was the most sensitive indicator,followed by ICMs and trophoblast outgrowth. As for the frequency of sister chromatid exchanges,there were no significant differences between MF-exposed and MF-unexposed groups in either chemicals.

  • Research Products

    (4 results)

All Other

All Publications (4 results)

  • [Publications] 飯島 純夫他: "磁場の生体への影響-特に発癌性,変異原性について-" 山梨医大紀要. 9. 15-22 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iijima,S.etal.: "Effects of static magnetic fields on sister Chromatid exchanges induction in human lymphocytes in vitro." Yamanashi Medical Journal. 8. (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Iijima S,Yamagata Z,Ooma T,Asaka A: "Biological effects of electromagnetic fields with special reference to their mutagenecity and carcinogenecity." Bulletin of Yamanashi Medical University.9. 15-22 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Iijima S,Yamagata Z,Takeshita T,Ooma T,Higurashi M,Asaka A: "Effects of static magnetic fields on sister chromatid exchanges induction in human lymphocytes in vitro." Yamanashi Medical Journal. 8. (1993)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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