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1992 Fiscal Year Final Research Report Summary

A study of HLA-region genes and their products in patients with autoimmune diseases.

Research Project

Project/Area Number 03670338
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field 内科学一般
Research InstitutionTokai University School of Medicine

Principal Investigator

MORIUCHI Junko  Assistant Professor of Internal Medicine 4, 医学部, 講師 (40125414)

Project Period (FY) 1991 – 1992
KeywordsSystemic lupus erythematosus / Sjogren's syndrome / Myasthenia gravis / Systemic sclerosis / Mixed connective tissue disease / HLA / RFLP / Complemeny C4
Research Abstract

At least one or several genes in human histocompatibility complex (HLA) play roles on the disease process of autoimmune diseases. In Caucasian, it is well established that individuals carrying HLA-DR3,DQ2 are more susceptible to many autoimmune diseases, such as systemic lupus erythematosus (SLE), Sjogren's syndrome (SS), myasthenia gravis (MG), systemic sclerosis (SSc).
In Japanese, however, susceptible gene(s) in the HLA region of diseases listed above are still unclear.
I studied HLA specificities by serological method, restriction fragment length polymorphism (RFLP) of genomic DNA, alleles of class II genes by using polymerase chain reaction-RFLP, and complement 4 (C4) allotypes in 86 patients of SLE, 69 of SS, 74 of MG, 33 of SSc and 36 of polymyositis and/or mixed connective tissue disease (PM/MCTD). The results obtained were as follows.
1) Among SLE patients, individuals positive for HLA-DR4 are more susceptible to lupus nephritis, but resistant to the involvement of central nervou … More s system than those without DR4. The frequency of the null allele of C4A gene (C4AQ0) is higher in SLE patients than in controls, however, deletion of C4A gene was not detected by RFLP method.
2) Higher incidences of HLA-DR53, DPB1*0201 and DQA1*03 were observed in female patients with MG when compared with the controls. The results indicate that Japanese patients with MG can be subdivided into at least two distinct groups. The first group consists of females whose disease onset is early and who have a high frequency of DR53, DPB1*0201 and DQ1*03. The second group consists of males and females with late onset of disease.
No particular HLA allele was found to be associated with the second group. Furthermore at least two distinct HLA class II genes were suggested to play roles on the disease onset of young females with MG.
3) Among SSc, the frequencies of HLA-DR2, C4BQ0 and anti-Scl 70 antibody were higher in patients with pulmonary fibrosis than those without it. Therefore, careful monitoring and treatment at an early stage of disease may necessary in patients the DR2 and C4BQ0. Less

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] Moriuchi J: "Association of the complement allele C4AQO with primary Sjogren's Syndrome in Japanese patients." Arthritis Rheum. 34. 224-227 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriuchi J: "Lack of deletion of complement C4 and steroid 2l-hydroxylase genes in Japanese patients with primary Sjogren's syndrome." J Rheum. 19. 700-703 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Morita K: "HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan." Ann Neurol. 29. 164-174 (1991)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Horiki T: "HLA-DPBl allele associates with early-onset myasthenia gravis in Japan." Neurology.

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 守内 順子: "シェーグレン症候群の遺伝的背景。" 臨床免疫. 24. 363-370 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 守内 順子: "Sjogren症候群の遺伝的素因ーHLAクラスII、III領域遺伝子を中心としてー" 医学のあゆみ. 163. 21-24 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Moriuchi J, Ichikawa Y, Takaya M,Shimizu H, Uchiyama M, Tsuji K, Wakisaka A, Arimori S: "Association of the complement allele C4AQ0 with primary Sjogren's syndrome in Japan." Arthritis Rheum. 34. 224-227 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriuchi J, Ichikawa Y, Takaya M, Shimizu H, Uchiyama M, Inoko H, Tsuji K, Arimori S: "Lack of deletion of complement C4 and steroid 21-hydroxylase genes in Japanese patients With primary Sjogren's syndrome." J Rheumatol. 19. 700-703 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Morita K, Moriuchi J, Inoko H, Tsuji K, Arimori S: "HLA class II antigens and DNA restriction fragment length polymorphism in myasthenia gravis in Japan" Ann Neurol. 29. 164-174 (1991)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Horiki T, Moriuchi J, Inoko H, Morita K, Shinohara Y, Ichikawa Y, Arimori S: "HLA-DPB1 allele associates with early-onset myasthenia gravis in Japan."

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriuchi J: "Genetic background of Sjogren's syndrome." Clin Immunol. 24. 363-370 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Moriuchi J: "Genetic factors of Sjogren's class II and III regions." Igakunoayumi. 163. 21-24 (1992)

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1994-03-24  

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