1992 Fiscal Year Final Research Report Summary
The production of cytokine in peripheral blood mononuclear cells of children with frequent infections and allergic children.
| Project/Area Number |
03670497
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Kochi medical school |
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Principal Investigator |
MORITA Hideo Kochi Medical School, Pediatrics, Instructor, 医学部, 講師 (00145129)
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| Co-Investigator(Kenkyū-buntansha) |
KURASHIGE Takanobu Kochi Medical School, Pediatrics, Professor, 医学部, 教授 (50117032)
HAMADA Fumihiko Kochi Medical School, Pediatrics, Associate, 医学部, 助手 (40208591)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Severely handicapped Children / Bronchial asthma / Atopic dermatitis / Interferon-gamma / NK activity / Lymphocyte subsets |
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| Research Abstract |
1.The production of interferon-gamma(IFN-gamma) in peripheral blood mononuclear cells(PBMCs) of severely handicapped children were studied. (1)The production of IFN-gamma in PBMCs of severely handicapped children with tube feedings was low and NK activity in these children was low. (2)The low production of IFN-gamma was continued in several years. We believe that our results were associated with frequent inferctions in severely handicapped children.
2.The production of IFN-gamma in PBMCs of allergic children were studied. (1)The production of IFN-gamma in PBMCs of atopic dermatitis children was lower than that of bronchial asthma children. (2)The production of IFN-gamma and the subset of CD45R^+CDw29^- cells in PBMCs of children with acute severe asthma were lower than that of stable asthma children. (3)When the production of IFN-gamma in PBMCs was low, lgE in supernatant was high. These results demonstrate the difference of cytokine production in PBMCs of bronchial asthma and atopic dermatitis and the appearance of acute severe asthma may contribute to increased lgE synthesis in bronchial asthma patients.
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