1992 Fiscal Year Final Research Report Summary
Measurements of erythrocyte Na pump receptor and lymphocyte adrenergic receptor in relation to digitalis-therapy in cardiac failure
| Project/Area Number |
03670501
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Pediatrics
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| Research Institution | Niigata University School of Medicine (1992)
大分医科大学 (1991) |
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Principal Investigator |
UCHIYAMA Makoto Niigata Univ. School of Med., Dept, Ped. Professor, 医学部, 教授 (80108050)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Cardiac failure / digitalis / Na pump receptor / adrenergic receptor / children |
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| Research Abstract |
We measured the numbers of erythrocyte Na pump receptor and lymphocyte adrenergic (beta -) receptor before and after treatment with digitalis in 9 children with congestive heart failure aged 4 months to 9 years. The following results (mean* SD) were obtained. 1)The number of beta -receptor was significantly decreased in children with heart failure than in age-matched control children (8.7*3.5 vs 16.1*5.3, P<0.01). 2)After treatment with digitalis, the number of beta -receptor was significantly increased (12.7*4.6, P<0.01) compared with that before treatment. However, it was still lower than that in control children, although this was not statistically significant. 3)The number of Na pump receptor was lower in children with cardiac failure than in control children, although this was not statistically significant (6.9*2.8 vs 7.4*2.1, P>0.05). 4)After treatment with digitalis, the number of Na pump receptor was significantly decreased (4.1*1.3,P<0.01) compared with that before treatment. However, it did not correlate with plasma concentration of digoxin.
These findings suggest that measurement of the number of beta -receptor may be useful in evaluating the condition of congestive cardiac failure, however measurement of the number of Na pump receptor may be less useful than expected for the same purpose.
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