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1993 Fiscal Year Final Research Report Summary

Relation between psychiatric function and immune function ; psychoneuroimmunological study on response to stress and psychiatric illness

Research Project

Project/Area Number 03670562
Research Category

Grant-in-Aid for General Scientific Research (C)

Allocation TypeSingle-year Grants
Research Field Psychiatric science
Research InstitutionMie University

Principal Investigator

KOMORI Teruhisa  Mie University Fuculty of Medicine, 医学部, 助手 (40178380)

Project Period (FY) 1991 – 1993
KeywordsPsychiatric function / Immune function / Stress / Neuroendocrine function / Depression / Antidepressants / Thyroid hormone / Olfactory bulb
Research Abstract

In 1991, we studied the effects of stress on immune function and the results indicated the effects of stress on immune function depend on the kind and duration of stress. Using restraint stress at 16 hours/day, 1-day restraint enhanced, whereas 3-day restraint suppressed immune function. Olfactory bulbectomy in mice, which are consedered as a depression model caused an inhibition of immune function and further suppression in response to 1-day restraint.
In 1992, we studied the effects of antidepressants on immune function. the administration of imipramine at 5mg/kg/day for 3 days suppressed immune function in normal mice, whereas ded not exert any effect on olfactory bulbectomized mice. The administration of imipramine for 10 days suppressed immune function in normal mice, whereas restored immune function in olfactory bulbectomized mice. Effects of antidepressents on immune function may depend on neuronal state. Among various interactions between neuroendocrine and immune system, we focused on the effects of thyroid function on immune function. because thyroid function is often relevant to depressive state. Results indecated that thyroid hormone may be importantin maintaining and stabilizing immune function in spite of immunosuppressive effect itself.
In the end of 1992 and 1993, we studied immune function in relation to neuroendocrine function, treatments and clinical course in depressive patients We get officially the informed consent from all patients. Although abnormal values in various immunologicalindices including CD4/8 and NK activity were found, any correlation to neuroendocrine function, the subytpes of depression or age was not found. Appropriate treatments, hoewver, improved clinical condition with normalization of neuroendocrine and immune indices. We are further studying the relation between the immune function and psychiatric illness.

  • Research Products

    (12 results)

All Other

All Publications (12 results)

  • [Publications] 小森照久: "抗うつ薬と免疫" 心身医学. 32. 53-58 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小森照久: "うつ病,および抗うつ薬の作用の精神神経免疫学的検討" 精神薬療基金研究年報. 23. 169-174 (1992)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] 小森照久: "視床下部下垂体一甲状腺系をめぐる精神神経免疫学的検討" 精神薬療基金研究年報. 24. 50-54 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Teruhisa Komori: "A new treatment for depression by fragrances:psychoneuroimmunological evaluation." Japanese Journal of Psychiatry and Neurology. 47. 717 (1993)

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Teruhisa Komori: "Effects of immobilization and fasting on plaque forming cell response in mice." International Journal of Neuroscinence. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Teruhisa Komori: "Effects of citrus fragrances on immune function and depressive states." Neuroimmunomodulation. (発表予定).

    • Description
      「研究成果報告書概要(和文)」より
  • [Publications] Teruhisa Komori, Junichi Nomura, Ryoichi Fujiwara and Mitchel M.Yokoyama: "Antidepressants and immunity" Shinshin-igaku. 32. 53-58 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teruhisa Komori and Junichi Nomura: "Psychoneuroimmunological studies on depression and effects of antidepressants" Annual Report of the Pharmacopsychiatry Research Foundation. 23. 169-174 (1992)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teruhisa Komori, Junichi Nomura and Ryoichi Fujiwara: "Psychoneuroimmunological studies on hypothalamopituitarythyroid axis" Annual Report of the Pharmacopsychiatry Research Foundation. 24. 50-54 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teruhisa Komori, Ryoichi Fujiwara, Masahiro Tanida and Junichi Nomura18GB04 : A new treatment for depression by fragrances : psychoneuroimmunological evaluation: Japanise Journal of Psychiatry and Neurology. 47. 717 (1993)

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teruhisa Komori, Ryoichi Fujiwara, Junichi Nomura and Mitchel M.Yokoyama: "Effects of immobilization and fasting on plaque forming cell response in mice" International Journal of Neuroscience. in press.

    • Description
      「研究成果報告書概要(欧文)」より
  • [Publications] Teruhisa Komori, Ryoichi Fujiwara, Masahiro Tanida and Junichi Nomura and Mitchel M.Yokoyama: "Effects of citrus fragrances on immune function and depressive states" Neuroimmunomodulation. in press.

    • Description
      「研究成果報告書概要(欧文)」より

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Published: 1995-03-27  

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