1992 Fiscal Year Final Research Report Summary
Diagnostic study of nipple discharge cases with no palpable mass : Diagnosis of histological features with fiberoptic ductoscopy of the breast.
| Project/Area Number |
03670592
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | First Department of Surgery, Sapporo Medical University, School of Medicine. |
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Principal Investigator |
OKAZAKI Minoru Sapporo Medical University. School of Medicine, Assistant Professor, 医学部, 講師 (30160667)
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| Co-Investigator(Kenkyū-buntansha) |
OKAZAKI Akira Sapporo Medical Univeristy. School of Medicine, Instructor, 医学部, 助手 (50213921)
NARIMATSU Eimei Sapporo Medical University. School of Medicine, Associate Professor, 医学部, 助教授 (80045343)
OKAZAKI Yutaka Sapporo Medical University. School of Medicine, Instructor, 医学部, 助手 (90203976)
ASAISHI Kazuaki Sapporo Medical University. School of Medicine, Associate Professor, 医学部, 助教授 (00045460)
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| Project Period (FY) |
1991 – 1992
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| Keywords | Nipple Discharge / Breast Cancer with No Palpable Mass / Intraductal Carcinoma / Ductal Washing Cytology / Ductography / Fiberoptic Ductoscopy of the Breast / Endoscopic Diagnosis / Curette Cytology under Endoscopic Guidance |
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| Research Abstract |
With the object of the improvement of daignostic accuracy in nipple discharge cases with no palpable mass, diagnostic results and findings of smear cytology, ductal washing cytology, fiberoptic ductoscopy and histological examinations were comparatively studied in 60 ducts of 58 cases in which histological diagnoses were confirmed. And silicafiberscopes of 0.45mm outer diameter were reorganized into fiberscopes of 0.75mm or 0.65mm outer diameters with an air channel.
Results : 1) The remodeling of the fiberscope could make it more endurable and made it easier to observe the ducts inside more than 5.0 cm away from the nipple. 2) Ductal washing cytology after smear cytology slightly improved a definitive diagnostic accuracy in breast cancers. Ductograms showed irregularities of caliber changes in many cases of cancers and ductography may be significant in a differential diagnosis foe nipple discharge cases. 3) Cancer was endoscopically recognized as superficially spreading lesions along intraductal walls and these findings were chatacteristically corresponded to intraductal proliferations showing irregular elevations seen on the histological sections. The intraductal papillomas formed intraductal colid nodules endoscopically in the ducts inside near the nipple, corresponding to polypous protrusions on the histological sections. 4) Tube curette cytology seemed to be available and to be an easy mathod to obtain a definitive diagnosis.
In conclusion, fiberoptic ductoscopy and tube curette cytology under an endoscopic guidance after other diagnostic procedures can have an important significance in the diagnosis for nipple discharge with no palpable mass and the early detection of breast cancers.
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