1992 Fiscal Year Final Research Report Summary
DEVELOPMENT OF A MESH - TYPE VASCULAR PROSTHESIS MADE OF SHAPE MEMORY PLASTIC
| Project/Area Number |
03670600
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
General surgery
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| Research Institution | The Jikei Univ. School of Med. |
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Principal Investigator |
AKABA Noritake The Jikel Univ. School of Med., The First Dept.of Surg., lecturer, 医学部, 講師 (60056728)
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| Co-Investigator(Kenkyū-buntansha) |
YAMAZAKI Mototaka Nippon Automation Co.LTD, Dept.of Development, researcher, 開発部, 研究員
YASUDA Yuichirou The Jikei Univ.School of Med.The First Dept.of Surg.assistant, 医学部, 助手 (80200509)
KOHNO Michio The Jikei Univ.School of Med.The First Dept.of Surg.assistant, 医学部, 助手 (90178228)
MIURA Kinji The Jikei Univ.School of Med.The First Dept.of Surg.assistant, 医学部, 助手 (30173975)
UJIIE Hisashi The Jikei Univ.School of Med.The First Dept.of Surg.assistant, 医学部, 助手 (20168686)
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| Project Period (FY) |
1991 – 1992
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| Keywords | shape memory plastic / biomaterial / vascular prosthesis / vascular graft / vascular stent / catheter therapy / rupture of aneurysm / percutaneous transluminal angioplasty (PTA) |
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| Research Abstract |
We attempted to use thermal shape memory plastic (SMP) for the treatment of vascular lesions. This device was used to prevent stenosis following PTA or to control the expansion of an aneurysm.
SMP has unique properties. First of all, when SMP is annealed at temperatures in excess of 120-200ﾟC, it will memorize that shape. Then, when heated with hot liquid to temperatures of 40-90ﾟC, it becomes limp and the shape can be transformed. When the new shape is cooled, it hardens and is fixed in that shape. When this transformed SMP is heated again at 40-90ﾟC, it returns to its original annealed shape. SMP devices for treating of vascular lesions were made. It was, originally a cylinder of mesh plate, which rolls up and becomes slender.
In an experiment in vivo, the device was put into test tubes containing tap water and water of 50ﾟC was added. Then the device returned to their original shapes as expected. An in vivo study was conducted using a canine. The device was bonded to the tips of catheters and inserted into the aorta from the distal artery. A 45-50ﾟC physiological saline solution was injected through the catheter. The device regained its original shapes as expected in arterial lumen and thus maintained blood flow. The results, however, varied due to factors, such as the curvature of the vessel, the injection speed and the volume of hot water.
The use of SMP devices will, if proved successful in further research, be a favorable procedure for the prevention of arterial re-stenosis or rupture of aortic aneurysm without preforming highly invasive procedures such as a laparotomy or aortic clamping.
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