1992 Fiscal Year Final Research Report Summary
The influence of FK506 on liver regeneration after partial hepatectomy in rats.
| Project/Area Number |
03670629
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| Research Category |
Grant-in-Aid for General Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Research Field |
Digestive surgery
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| Research Institution | KYUSHU UNIVERSITY
OITA MEDICAL UNIVERSITY |
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Principal Investigator |
ICHIMIYA Hitoshi KYUSHU UNIVERSITY FACULTY OF MEDICINE Assistant Professor, 医学部, 助手 (10183170)
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| Co-Investigator(Kenkyū-buntansha) |
SATOH Hiroshi KYUSHU UNIVERSITY FACULTY OF MEDICINE Assistant Professor, 医学部, 助手
CHIJIIWA Kazuo KYUSHU UNIVERSITY FACULTY OF MEDICINE Lecturer, 医学部, 講師 (90179945)
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| Project Period (FY) |
1991 – 1993
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| Keywords | FK506 / Liver Regeneration / Hepatectomy / Protein Content / DNA Content / DNA Synthesis / Liver Enzyme |
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| Research Abstract |
The effects of FK506, an active immunosuppressant, on liver regeneration were studied at various periods of regeneration and with various dosages of the drug in partially hepatectomized rats. Three different dosages of FK506 on the vehicle were injected intramuscularly for three days prior to and immediately after a partial hepatectomy. The body weight, liver weight, protein content, DNA synthesis, activities of liver enzymes and the weight of food intake were all examined from twelve hour to seven days after the operation. The treatment with FK506 resulted in a body weight loss, which was smallest in the rats treated with the dosage clinically used. A slight significant increase was seen in the calculated % regeneration of the liver weight in the group treated with FK506. In spite of the suppression of DNA synthesis in the rats treated with FK506 one day after a partial hepatectomy, the restoration of the DNA content in the regenerating livers was not inhibited in the rats treated with FK506 compared to those treated with the vehicle. On the restoration of protein content, a stimulatory effect was seen in the FK506 treated animals. Food intake was significantly suppressed in the rats treated with FK506. This suppression increased as the dosage increased. There were no significant differences in the serum activities of the liver enzymes among each group. The suppression of food intake led to a body weight loss, but not to liver regeneration. We thus concluded that FK506 does not inhibit, but slight stimulates liver regeneration after a partial hepatectomy in rats.
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